Results 91 to 100 of about 13,244,565 (235)

Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS

Frontiers in Pharmacology
IntroductionCucurbitacin, a class of triterpenoid compounds isolated from Pedicellus Melo, possesses various biological activities and is the primary active component of cucurbitacin tablets (CUT) used to treat chronic hepatitis and primary liver cancer.
Chun-nan Zhang, Zhi-bin Wang, Rui-tong Du, Shu-lu Zhang, Chu-qiao Wang, Meng Wang, Li-hong Wu, De-qiang Yang, Chen Wang   +8 more
doaj   +1 more source

Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation

BMC Complementary and Alternative Medicine, 2018
Background Cucumis prophetarum var. prophetarum is used in Saudi folk medicine for treating liver disorders and grows widely between Abha and Khamis Mushait City, Saudi Arabia.
Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Hesham S. M. Soliman, Sivakumar Annadurai, Fathi T. Halaweish   +5 more
doaj   +1 more source

Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects

Molecules, 2021
During a phytochemical investigation of the unripe fruits of Rubus chingii Hu (i.e., Fructus Rubi, a traditional Chinese medicine named “Fu-Pen-Zi”), a number of highly oxygenated terpenoids were isolated and characterized.
Jiang Wan, Xiao-Juan Wang, Nan Guo, Xi-Ying Wu, Juan Xiong, Yi Zang, Chun-Xiao Jiang, Bing Han, Jia Li, Jin-Feng Hu   +9 more
doaj   +1 more source

The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas [PDF]

, 2008
Purpose: The signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in most cancers, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients.
Abou-Ghazal, Mohamed, Fuller, Gregory N., Heimberger, Amy B., Hiroka, Nobuyoshi, Kong, Ling-Yuan, Priebe, Waldemar, Qiao, Wei, Reina-Ortiz, Chantal, Sawaya, Raymond, Wei, Jun, Yang, David S.   +10 more
core   +1 more source

Multi‐Omics Evidence Linking Gualou Xiebai Banxia Decoction Intervention to Atherosclerosis Mitigation and Gut Microbiota–Bile Acid Signatures in ApoE−/− Mice

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Gualou Xiebai Banxia Decoction (GXBD) promotes atherosclerotic plaque stabilization via the “gut microbiota—bile acid—host” axis. GXBD treatment remodels the gut microbiota, promoting the production of secondary bile acids (11‐LCA and 23‐DCA).
Rutao Bian, Li Zhang, Jun Zhu, Xuegong Xu   +3 more
wiley   +1 more source

Inhibition of SENP5 by Cucurbitacin B Suppresses Cell Growth and Promotes Apoptosis in Osteosarcoma Cells [PDF]

, 2015
Purpose: To investigate the effect of cucurbitacin B on the expression of SUMO-specific proteases (SENP5).Methods: Effect of cucurbitacin B (10-50 mg/mL) on viability of U2OS and Saos-2 cells was determined in a plate reader by recording absorbance at ...
Liu, S, Liu, Z, Zhao, J, Zhong, J
core   +2 more sources

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Kutkins- A Review of Chemistry and Pharmacology [PDF]

, 2004
Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste.
Singh, Amrit Pal
core   +2 more sources

Steroid hormone signaling is involved in the age-dependent behavioral response to sex pheromone in the adult male moth Agrotis ipsilon [PDF]

, 2013
In most animals, including insects, male reproduction depends on the detection and processing of female-produced sex pheromones. In the male moth, Agrotis ipsilon, both behavioral response and neuronal sensitivity in the primary olfactory center, the ...
A. Maria, C. Gadenne, L. Duportets, S. Debernard, S. Vitecek   +4 more
core   +2 more sources

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source