Results 181 to 190 of about 13,244,565 (235)

Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation.

Toxicology in Vitro, 2023
Ferroptosis is a unique type of cell death which co-exists with elevated iron, suppressed antioxidative function and increased lipid peroxidation. Recent studies have shown that cancer cells are particularly susceptible to the compounds with ferroptotic ...
Filiz Bakar-Ates, Erva Ozkan
semanticscholar   +1 more source

Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy

Journal of Cellular Biochemistry, 2017
ABSTRACTLack of effective anti‐cardiac hypertrophy drugs creates a major cause for the increasing prevalence of heart failure. In the present study, we determined the anti‐hypertrophy and anti‐fibrosis potential of a natural plant triterpenoid, Cucurbitacin B both in vitro and in vivo.
Yang Xiao, Zheng Yang, Qing‐Qing Wu, Xiao‐Han Jiang, Yuan Yuan, Wei Chang, Zhou Yan Bian, Jin Xiu Zhu, Qi‐Zhu Tang   +8 more
openaire   +2 more sources

Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2.

Phytomedicine
BACKGROUND Effective therapies for malignant breast cancer are urgently needed, as resistance and immunosuppressive microenvironments limit PD-1 blockade efficacy.
Qianqian Xu, Zeyu Jiang, Yuqi Pan, Sheng Li, Zehong Cao, Shengjie Hua, Ruolan Yang, Qinman He, Hao Wu, Hongmei Wen, Bo Hang, Hongli Yu, Xinzhi Wang   +12 more
semanticscholar   +1 more source

Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma

European Archives of Oto-Rhino-Laryngology, 2008
Cucurbitacins are compounds isolated from various plant families, which have been used as folk medicines for centuries in countries such as India and China because of their wide spectrum of pharmacological activities such as cytotoxic, anti-inflammatory, and anticancer effects. Accumulated evidences have shown that cucurbitacin B inhibits the growth of
Tingyan, Liu, Meixia, Zhang, Hongliang, Zhang, Chunyan, Sun, Yihui, Deng   +4 more
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Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells

Planta Medica, 2018
AbstractBreast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis.
Kanthanadon, Dittharot, Sumana, Dakeng, Parichat, Suebsakwong, Apichart, Suksamrarn, Pimpicha, Patmasiriwat, Moltira, Promkan   +5 more
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Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Biochemical and Biophysical Research Communications, 2015
Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of
Zheng Jun Li, Jung-Min Shin, Dae-Kyoung Choi, Seul Ki Lim, Tae-Jin Yoon, Young Ho Lee, Kyung-Cheol Sohn, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee   +11 more
openaire   +2 more sources

Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2/HO‐1 pathway

Phytotherapy Research
Osteoarthritis (OA) is a complicated joint disorder characterized by inflammation that causes joint destruction. Cucurbitacin B (CuB) is a naturally occurring triterpenoid compound derived from plants in the Cucurbitaceae family. The aim of this study is
Chao Lou, Yuqin Fang, Y. Mei, Wei Hu, Liaojun Sun, Chen Jin, Hua Chen, Wenhao Zheng   +7 more
semanticscholar   +1 more source

Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer.

Journal of Ethnopharmacology, 2021
ETHNOPHARMACOLOGICAL RELEVANCE Cucurbitacin B (CuB), extracted from muskmelon pedicel, is a widely available triterpenoid molecule that exerts influence on various biological activities.
Haoyue Zhang, Bei Zhao, Hui Wei, Hairong Zeng, Dong Sheng, Yang Zhang   +5 more
semanticscholar   +1 more source

Abstract 2686: The combination of Cucurbitacin B and Evodiamine inhibits cell migration and propagation, and induces apoptosis in in vitro glioma cells

Cancer Research, 2023
Glioblastoma is a lethal brain tumor. Despite aggressive treatment, the median survival time is 6 to 12 months. These tumors acquire resistance against many therapeutic regimens.
Vrutti V. Mehta, K. Benzeroual
semanticscholar   +1 more source

Studies toward the Total Syntheses of Cucurbitacins B and D

The Journal of Organic Chemistry, 2010
Synthetic efforts toward the convergent construction of the tetracyclic triterpenoids cucurbitacins B and D are described. The results of a Diels-Alder study examining the effects of steric and electronic variations of 2-methyl-2-cyclohexenone on the endo/exo-diastereoselectivity of the reaction are presented.
Michael E, Jung, Rebecca M, Lui
openaire   +2 more sources