Results 201 to 210 of about 17,883 (244)

The biosynthesis of cucurbitacin B

Journal of the Chemical Society D: Chemical Communications, 1970
Evidence is presented that is consistent with cucurbitacin B being biosynthesized via cycloartenol or parkeol but not through the intermediacy of lanosterol.
J. Malcolm Zander, Donald C. Wigfield
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Ethanol enhances cucurbitacin B-induced apoptosis by inhibiting cucurbitacin B-induced autophagy in LO2 hepatocytes

Molecular & Cellular Toxicology, 2016
Ethanol is a common risk factor for liver injury. Cucurbitacin B (CuB) is a natural product with potent cytotoxic activities mediated by inducing apoptosis. This study investigated the effect of ethanol on CuB-induced cytotoxicity in LO2 hepatocytes. Low concentration of ethanol alone showed no significant cytotoxic effect on LO2 cells.
Qian Ding, Jiaolin Bao, Wenwen Zhao, Jinjian Lu, Hong Zhu, Xiuping Chen   +5 more
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NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

Journal of Molecular Endocrinology, 2021
Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal-induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with upregulated caspase 1 protease and IL-1β in macrophages.
Ying, Xue, Ran, Li, Ping, Fang, Zheng-Qin, Ye, Yong, Zhao, Yun, Zhou, Ke-Qin, Zhang, Ling, Li   +7 more
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Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity

Archives of Biochemistry and Biophysics, 2020
Signal transducer and activator of transcription 3 (STAT3) is expressed aberrantly in multiple tumors, including gastric cancer (GC). STAT3 overexpression and excessive activation have been confirmed to play vital roles in tumorigenesis. Cucurbitacin B (CuB) is a natural product with potent anti-cancer activities in solid tumors.
Jiaxin, Xu, Yunhe, Chen, Rui, Yang, Tong, Zhou, Wei, Ke, Yuan, Si, Shusheng, Yang, Te, Zhang, Xuewen, Liu, Liang, Zhang, Ke, Xiang, Yang, Guo, Ying, Liu   +12 more
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Antitumor activity and mechanism of cucurbitacin B in A549/DDP cells

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
Cucurbitacin B (CuB) is a class of tetracyclic triterpenoids isolated from Cucurbitaceae with a wide range of anti-inflammatory and anti-tumor activities, mainly used in hepatitis and hepatocellular carcinoma, while there is relatively little research and application of this drug for lung cancer. In this study, CuB was administered on A549/DDP cells to
Xinyuan, Yu, Weiwei, Chen, Jinjie, Zhang, Xinfu, Gao, Qidi, Cui, Zheng, Song, Jing, Du, Wenwen, Lv   +7 more
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Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy

Journal of Cellular Biochemistry, 2017
ABSTRACTLack of effective anti‐cardiac hypertrophy drugs creates a major cause for the increasing prevalence of heart failure. In the present study, we determined the anti‐hypertrophy and anti‐fibrosis potential of a natural plant triterpenoid, Cucurbitacin B both in vitro and in vivo.
Yang Xiao, Zheng Yang, Qing‐Qing Wu, Xiao‐Han Jiang, Yuan Yuan, Wei Chang, Zhou Yan Bian, Jin Xiu Zhu, Qi‐Zhu Tang   +8 more
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Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma

European Archives of Oto-Rhino-Laryngology, 2008
Cucurbitacins are compounds isolated from various plant families, which have been used as folk medicines for centuries in countries such as India and China because of their wide spectrum of pharmacological activities such as cytotoxic, anti-inflammatory, and anticancer effects. Accumulated evidences have shown that cucurbitacin B inhibits the growth of
Tingyan, Liu, Meixia, Zhang, Hongliang, Zhang, Chunyan, Sun, Yihui, Deng   +4 more
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Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells

Planta Medica, 2018
AbstractBreast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes including aberrant promoter methylation plays a critical role in human breast carcinogenesis.
Kanthanadon, Dittharot, Sumana, Dakeng, Parichat, Suebsakwong, Apichart, Suksamrarn, Pimpicha, Patmasiriwat, Moltira, Promkan   +5 more
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Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Biochemical and Biophysical Research Communications, 2015
Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of
Zheng Jun Li, Jung-Min Shin, Dae-Kyoung Choi, Seul Ki Lim, Tae-Jin Yoon, Young Ho Lee, Kyung-Cheol Sohn, Myung Im, Young Lee, Young-Joon Seo, Chang Deok Kim, Jeung-Hoon Lee   +11 more
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Studies toward the Total Syntheses of Cucurbitacins B and D

The Journal of Organic Chemistry, 2010
Synthetic efforts toward the convergent construction of the tetracyclic triterpenoids cucurbitacins B and D are described. The results of a Diels-Alder study examining the effects of steric and electronic variations of 2-methyl-2-cyclohexenone on the endo/exo-diastereoselectivity of the reaction are presented.
Michael E, Jung, Rebecca M, Lui
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