Results 191 to 200 of about 13,244,565 (235)

Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway

Phytotherapy Research
Osteosarcoma is a common malignant bone tumour characterised by an aggressive metastatic potential. The tumour microenvironment, particularly the M2‐polarised macrophages, is crucial for tumour progression. Cucurbitacin B (CuB), a triterpenoid derivative,
Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui   +7 more
semanticscholar   +1 more source

Cucurbitacin B targets STAT3 to induce ferroptosis in non-small cell lung cancer.

European Journal of Pharmacology
Cucurbitacin B (CuB) is a compound found in plants like Cucurbitaceae that has shown promise in fighting cancer, particularly in lung cancer. However, the specific impact of CuB on ferroptosis and how it works in lung cancer cells has not been fully ...
Zeyao Zeng, Yingying Hu, Jing Xiang, Jiating Su, Huiting Tan, Tianli Lai, Xinming Chen, Guixuan Fang, Li Li, Lianxiang Luo   +9 more
semanticscholar   +1 more source

Callus formation and cucurbitacin B accumulation in Ecballium elaterium callus cultures

Fitoterapia, 2003
Ecballium elaterium fruit juice is used for the treatment of sinusitis in Turkish folk medicine. The aim of this study was to increase the yield of cucurbitacin B, an anti-inflammatory compound previously isolated in various organs of E. elaterium, through tissue culture techniques.
Yesilada, E, Memisoglu, M, Toker, G, Toker, MC   +3 more
openaire   +3 more sources

Cucurbitacin B Inhibits the Malignancy of Esophageal Carcinoma through the KIF20A/JAK/STAT3 Signaling Pathway.

The American Journal of Chinese Medicine
This study intends to explore the effects of Cucurbitacin B (CuB) and KIF20A on esophageal carcinoma (ESCA). Data were downloaded from the Cancer Genome Atlas (TCGA) database.
Chao Liu, J. Ji, Chenglin Li
semanticscholar   +1 more source

Transcription Factor CmWRKY13 Regulates Cucurbitacin B Biosynthesis Leading to Bitterness in Oriental Melon Fruit (Cucumis melo var. Makuwa Makino).

Journal of Agricultural and Food Chemistry
Bitterness, caused by cucurbitacin B (CuB), is one of the important traits that affects melon fruit quality and consumer acceptance. Therefore, the detailed mechanism behind the regulation of CuB biosynthesis on melon fruit needs to be further explored ...
Fei Luo, Yushan Huang, Yinhan Sun, Jingyue Guan, Meng Li, Tao Liu, Hongyan Qi   +6 more
semanticscholar   +1 more source

Disposition and fate of cucurbitacin B in five species of diabroticites

Journal of Chemical Ecology, 1985
Five species of diabroticites with different host-plant preferences produced an essentially identical array of metabolites when fed radiolabeled cucurbitacin B synthesized in vivo and purified fromCucurbita maxima Duchesne seedlings. All species excreted the bulk of the cucurbitacin (67,17-94.59% total dpm), permanently sequestered a small proportion ...
J E, Ferguson, R L, Metcalf, D C, Fischer   +2 more
openaire   +2 more sources

Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer

European Journal of Pharmacology, 2008
Combination therapy with multiple drugs is a common practice in the treatment of cancer. The promising clinical activity of docetaxel has promoted considerable interest in combining it with other antitumor agents. To determine whether cucurbitacin B can enhance chemosensitivity to docetaxel in laryngeal cancer, in the present study, we investigated the
Tingyan, Liu, Meixia, Zhang, Hongliang, Zhang, Chunyan, Sun, Xiaolin, Yang, Yihui, Deng, Wenyue, Ji   +6 more
openaire   +2 more sources

Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages

Immunopharmacology and Immunotoxicology, 2015
Cucurbitacin B (CuB) is a triterpenoid that is widely distributed in the plant kingdom and has a variety of biological activities. However, the immunomodulatory and anti-inflammatory effects of CuB have not been well characterized. Therefore, in this study, we investigated the effects of CuB on parameters related to antigen presentation and T-cell ...
Minju, Kim, Sun Young, Park, Mei Ling, Jin, Geuntae, Park, Hong-Joo, Son   +4 more
openaire   +2 more sources

Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α

European Journal of Pharmacology, 2014
Cucurbitacin B is a triterpenoid compound isolated from Trichosanthes kirilowii Maximowicz, which has been used in oriental medicine for its antitumor activities. However, the mechanisms by which cucurbitacin B inhibits tumor growth are not fully understood.
Juan, Ma, Ying, Zi Jiang, Hui, Shi, Chunliu, Mi, Jing, Li, Ji, Xing Nan, Xue, Wu, Jung, Joon Lee, Xuejun, Jin   +8 more
openaire   +2 more sources

Determination of Cucurbitacin B in Trichosanthes dioica Roxb by HPTLC

Pharmacognosy Communication, 2014
Background: Trichosanthes dioica Roxb, (Cucurbitaceae), is a perennial herb distributed in Asian subcontinent. The pointed gourd is mainly cultivated as a vegetable. The Charaka Samhita prescribes its use in treating jaundice and alcoholism. Ayurvedic literature depicts its use as a diuretic, cardiotoinc, antiulcer and a laxative. Recent research trend
Joy Ashish Solomon, Aditya Ganeshpurkar, Nilesh Shrivastava, Divya Bansal, Nazneen Dubey   +4 more
openaire   +1 more source