Results 21 to 30 of about 2,327 (197)

Development and Validation of a New Analytical HPLC-PDA Method for Simultaneous Determination of Cucurbitacins B and D from the Roots of Trichosanthes kirilowii

Journal of Chemistry, 2022
Trichosanthes kirilowii, one of the herbal formulas named SH003, has been used for treatment in traditional medicine. This paper aimed to analyze the marker compounds from the roots of T. kirilowii and evaluate a validation method for cucurbitacins B and
Hyoung Ja Kim, Jae Yeol Lee, Chunhoo Cheon, Seong-Gyu Ko   +3 more
doaj   +1 more source

Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells

Biochemistry and Biophysics Reports, 2020
Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood.
Isabella J. Brouwer, Jacoba J. Out-Luiting, Maarten H. Vermeer, Cornelis P. Tensen   +3 more
doaj   +1 more source

Site-directed mutagenesis identified the key active site residues of 2,3-oxidosqualene cyclase HcOSC6 responsible for cucurbitacins biosynthesis in Hemsleya chinensis

Frontiers in Plant Science, 2023
Hemsleya chinensis is a Chinese traditional medicinal plant, containing cucurbitacin IIa (CuIIa) and cucurbitacin IIb (CuIIb), both of which have a wide range of pharmacological effects, including antiallergic, anti-inflammatory, and anticancer ...
Xia Li, Xia Li, Geng Chen, Geng Chen, Qing-Qing Gao, Qing-Qing Gao, Chun-Fan Xiang, Chun-Fan Xiang, Cheng-Xiao Yuan, Cheng-Xiao Yuan, Xiao-Ning Li, Yan-Yu Shu, Yan-Yu Shu, Guang-Hui Zhang, Guang-Hui Zhang, Yan-Li Liang, Yan-Li Liang, Sheng-Chao Yang, Chen-Xi Zhai, Yan Zhao, Yan Zhao   +20 more
doaj   +1 more source

Ecology and Evolutionary History of Diabrotica Beetles—Overview and Update

Insects, 2022
An overview is given on several aspects of evolutionary history, ecology, host plant use, and pharmacophagy of Diabrotica spp. with a focus on the evolution of host plant breadth and effects of plant compounds on natural enemies used for biocontrol of ...
Astrid Eben
doaj   +1 more source

In Vitro Sprouted Plantlets of Citrullus colocynthis (L.) Schrad Shown to Possess Interesting Levels of Cucurbitacins and Other Bioactives against Pathogenic Fungi

Plants, 2022
Cucurbitacins, structurally different triterpenes mainly found in the members of Cucurbitaceae, possess a vast pharmacological potential. Genus Cucurbita, Cucumis, and Citrullus are affluent in these bioactive compounds, and, amongst them, Citrullus ...
Belsem Marzouk, Meher Refifà, Serena Montalbano, Annamaria Buschini, Stefano Negri, Mauro Commisso, Francesca Degola   +6 more
doaj   +1 more source

VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation [PDF]

, 2014
Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
He, Xian-Hui, Ji, Fang, Liu, Kun-Peng, Liu, Pei-Yan, Liu, Xiao-Ming, Lu, Qun, NC DOCKS at East Carolina University, Ouyang, Dong-Yun, Xu, Li-Hui, Zhang, Yan-Ting   +9 more
core   +3 more sources

Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots

Frontiers in Plant Science, 2022
In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but have
Aldo Almeida, Lemeng Dong, Theis H. Thorsen, Morten H. Raadam, Bekzod Khakimov, Natalia Carreno-Quintero, Sotirios C. Kampranis, Søren Bak   +7 more
doaj   +1 more source

Inhibitory Activity of Leaves Extracts of Citrullus colocynthis Schrad. on HT29 Human Colon Cancer Cells [PDF]

, 2016
Aims: Citrullus colocynthis is a plant endemic in Asia, Africa and in the Mediterranean basin. It is used in folk medicine against infections, inflammations and cardiovascular and immune-related diseases.
Aouni, M, Arru, Laura, Bekkouche, K, Buschini, A., Galati, S, Jamali, Ca, Marzouk, B, Marzouk, Z, Mussi, F   +8 more
core   +1 more source

Bottle Gourd (Lagenaria Siceraria) Toxicity: A “Bitter” Diagnostic Dilemma [PDF]

Journal of Clinical and Diagnostic Research, 2014
Consumption of a glass of bottle gourd juice is thought to work as a health “tonic” and part of traditional healthy living practices in India. The juice may in certain circumstances turn bitter with increased levels of the cytotoxic compound called ...
Khalid Ismail Khatib, Kapil Sharad Borawake   +1 more
doaj   +1 more source

Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society [PDF]

, 2017
Wild edible plants (WEPs) are part of the cultural and genetic heritage of different regions of the world. In times of famine and scarcity, these sources of nutrients and health-promoting compounds have received high importance mainly in rural and ...
Abbasi, Abdelli, Aceituno-Mata, Al-Qura'n, Alarcón, Amaducci, Amalraj, Amirul, Ana Maria Carvalho, Anderson, AOAC, Bacchetta, Baker, Barreira, Barros, Barros, Barros, Barros, Barros, Barros, Barros, Barros, Barros, Barroso, Bianco, Bicho, Brogren, Caldas, Caleja, Caleja, Caleja, Carocho, Carr, Carvalho, Carvalho, Carvalho, Castañeda-Álvarez, Chen, Chen, Chen, Costa, Cowan, Da Rocha, Dias, Dodson, EFSA, EFSA, EFSA, EMA, EMA, European Commission, Fajardo, Fernandes, Galli, García Herrera, García-Herrera, García-Herrera, García-Herrera, García-Jiménez, Gille, Glensk, Gry, Guerra, Guil, Guil-Guerrero, Guil-Guerrero, Guil-Guerrero, Guimarães, Gupta, Güçlü-Üstündağ, Hylands, Hylands, Isabel C.F.R. Ferreira, José Pinela, Kaur, Kaushik, Kemal, Kim, Kiuchi, Kovács, Kovács, Kristanc, Kristanc, Kumarasamy, Lee, Li, Liebman, Magos Brehm, Marostica, Martins, Martins, Martins, Mason, Maxted, Menendez-Baceta, Menendez-Baceta, Molina, Monzote, Morales, Morales, Morales, Morales, Morales, Morales, Muzquiz, Muñoz, Niki, Niki, Nikolić, Oda, Oliveira, Oobayashi, Ottaway, Otten, Palaniswamy, Pandey, Pardo-de-Santayana, Pereira, Pereira, Pereira, Petropoulos, Petropoulos, Pinela, Pinela, Pinela, Pinela, Pinela, Pinela, Pinela, Pinela, Podolak, Pohlmann, Quintaes, Radulović, Ranfa, Renna, Reyes-García, Roeder, Réthy, Saini, Schippmann, Simopoulos, Sinha, Smith, Smolarz, Smolin, Souci, Stein, Street, Swaminathan, Sánchez-Mata, Sánchez-Mata, Sõukand, Sõukand, Tardio, Tardío, Tardío, Tardío, Tardío, Teixeira, The European Parliment and the Council of the European Union, The Plant List, Thomassen, Torbati, Torija-Isasa, Trichopoulou, Tucker, Turner, Tuttolomondo, Vacillotto, Vasquez, Vermerris, Vermerris, Vinha, Vizgirdas, Wiedenfeld, Wretensjö, Wu, Zhang, Zhang, Zhao, Łuczaj, Łuczaj, Żołnierczyk   +183 more
core   +1 more source