Results 41 to 50 of about 1,810,948 (240)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Craving on the move: targeting smoking memories with a novel 3MDR–smoking cessation protocol

Frontiers in Psychiatry
IntroductionImproved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories.
Annel P. Koomen, Anne Marije Kaag, Kees A. M. Jongenelen, Rianne Wouters, Hein J. F. van Marle, Hein J. F. van Marle, Hein J. F. van Marle, Hein J. F. van Marle, Odile A. van den Heuvel, Odile A. van den Heuvel, Odile A. van den Heuvel, Ysbrand D. van der Werf, Ysbrand D. van der Werf, Taco J. De Vries, Taco J. De Vries   +14 more
doaj   +1 more source

The role of native phonology in spontaneous imitation: Evidence from Seoul Korean

Laboratory Phonology, 2019
This study investigates the role of phonology in spontaneous imitation in Seoul Korean speakers’ imitation of aspirated stops by comparing the primary and non-primary cues.
Harim Kwon
doaj   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Effect of stress on the relationship between relief-seeking and cue-induced alcohol craving and anxiety: A virtual reality cue exposure study

Comprehensive Psychiatry
Objective: Stress is well-known to increase alcohol craving and alcohol cue-induced anxiety in individuals with alcohol use disorder (AUD). While previous research suggests that individuals who drink for relief experience strong alcohol cravings and ...
Lara R. Piccoli, Lucy Albertella, Alexandra Ghiţă, Chao Suo, Shuo Chen, José Gutiérrez-Maldonado, Karyn Richardson, Murat Yücel, Rico Sze Chun Lee   +8 more
doaj   +1 more source

The relationship between amygdala activation and passive exposure time to an aversive cue during a continuous performance task. [PDF]

PLoS ONE, 2010
The allocation of attention modulates negative emotional processing in the amygdala. However, the role of passive exposure time to emotional signals in the modulation of amygdala activity during active task performance has not been examined.
Irina A Strigo, Alan N Simmons, Scott C Matthews, Arthur D Bud Craig   +3 more
doaj   +1 more source

It is never as good the second time around: Brain areas involved in salience processing habituate during repeated drug cue exposure in treatment engaged abstinent methamphetamine and opioid users

NeuroImage, 2021
The brain response to drug-related cues is an important marker in addiction-medicine. However, the temporal dynamics of this response in repeated exposure to cues are not well known.
Hamed Ekhtiari, Rayus Kuplicki, Robin L. Aupperle, Martin P. Paulus   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cue reactivity to self-harm cues: the development of a systematic treatment intervention for deliberate self-harm

, 2009
There is increasing awareness of the prevalence of deliberate self-harm (DSH) although the phenomenon is still poorly understood. Those who self-harm often have a poor long-term prognosis, yet systematic focused treatment interventions are scarce.
Hepworth, Claire Rachel
core   +1 more source