Results 81 to 90 of about 17,236 (327)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cocaine Cues Used in Experimental Research: A Systematic Review

Brain Sciences
Aims: Cue exposure therapy (CET) is a promising treatment approach for cocaine substance use disorder (SUD). CET specifically targets the psychological and physiological responses elicited by drug-related cues, aiming to reduce their motivational impact.
Eileen Brobbin, Natalie Lowry, Matteo Cella, Alex Copello, Simon Coulton, Jerome Di Pietro, Colin Drummond, Steven Glautier, Ceyda Kiyak, Thomas Phillips, Daniel Stahl, Shelley Starr, Lucia Valmaggia, Colin Williams, Paolo Deluca   +14 more
doaj   +1 more source

Craving cannabis : a meta-analysis of self-report and psychophysiological cue—reactivity studies

, 2016
Aims: To estimate the magnitude of cannabis cue–reactivity responses in people who regularly use cannabis. Methods: EMBASE, PUBMED, PsycINFO, PsycEXTRA and Project CORK were searched for within-subject comparison studies published between January 2000 ...
Lyras, Stephanie, Kavanagh, David J., Olivier, Jake, Norberg, Melissa M., Kavanagh, David J, Norberg, Melissa M   +5 more
core   +1 more source

The Effect of Alcohol Cue Exposure on Tobacco-Related Cue Reactivity: A Systematic Review

Alcohol and Alcoholism, 2021
Abstract Aims To examine the effect of alcohol cue exposure on tobacco-related cravings, self-administration and other measures of tobacco-related cue reactivity. Methods We searched Medline, PsycINFO, Embase, CINAHL and Scopus from ...
Emma V Ritchie, Chelsea Fitzpatrick, Paul E Ronksley, Alexander A Leung, Sydney Seidel, Daniel S McGrath   +5 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Increased EEG gamma power under exposure to drug-related cues: a translational index for cue-elicited craving in METH-dependent individuals

BMC Psychiatry, 2023
Background This study explored the feasibility of using EEG gamma-band (30–49 Hz) power as an index of cue-elicited craving in METH-dependent individuals.
Dong-xu Li, Xiang-yi Zhou, Qian-qian Lin, Yue Wu, Cheng Hu, Zhi-hua Shen, Yong-guang Wang   +6 more
doaj   +1 more source

Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats [PDF]

Learning & Behavior, 2015
In the present study, we examined the effects of extinction of sucrose-predictive contextual cues and/or sucrose satiation on the expression of sucrose cue reactivity in a rat model of relapse. Context extinction was imposed by housing rats in their home cage or in the operant conditioning chamber for 17 h prior to testing.
John H, Harkness, Jason, Wells, Sierra, Webb, Jeffrey W, Grimm   +3 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Factors related to cue reactivity in gamblers

, 2012
For regular gamblers, physiological arousal and subjective excitement are known to occur in response to gambling-related cues. The present study seeks to use a cue exposure paradigm to explore two factors related to cue reactivity in gambling.
Seifert, Cheryl Ann
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source