Results 91 to 100 of about 5,658,512 (359)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Cross-cultural collaboration for inclusive global value chain: a case study of rattan industry

open access: yesInternational Journal of Emerging Markets, 2019
Purpose The purpose of this paper is to understand how the cross-cultural collaboration between developed market and emerging economies promotes an inclusive global value chain (GVC) through innovation and technology transfer.
A. Pratono
semanticscholar   +1 more source

Between plumbers and mushrooms. The cinema adaptation of the classic videogame Super Mario Bros

open access: yesDoxa Comunicación
In this article, cinema and video games converge with the aim of analyzing the audiovisual treatment of the characters who acquire an important role in the film Super Mario Bros: The Movie (Horvarth and Jelenic, 2023) and the transformations raised with
María Nieves Corral Rey   +1 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Modified 2-tuple Linguistic Neutrosophic Hybrid GRA Framework for Comprehensive Strength Evaluation for High-Quality Development in the Cultural Industry [PDF]

open access: yesNeutrosophic Sets and Systems
The evaluation of comprehensive strength for the high-quality development of the cultural industry is a systematic assessment of the overall performance of the cultural sector across multiple dimensions.
Xiuhuan Feng   +3 more
doaj   +1 more source

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