Results 61 to 70 of about 1,442,299 (364)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Navigating the Copyright Landscape: Iran's Journey towards Global Integration [PDF]

International Journal of Information Science and Management
This study aims to explore the issues, factors, and outcomes of Iran's accession to international copyright treaties, offering practical recommendations. The research uses a qualitative approach with grounded theory methodology.
Dariush Matlabi
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

New energy vehicle battery state of charge prediction based on XGBoost algorithm and RF fusion

Energy Informatics
As the most important component of new energy electric vehicles, lithium-ion batteries may suffer irreversible damage to the battery due to an abnormal state of charge. Nevertheless, the extant research on charge prediction predominantly employs a single
Changyou Lei
doaj   +1 more source

A Poet as an Art Manager: A Maria Osipova Project “Masha Writes” (2018)

Филологический класс, 2020
The article discusses the content and cultural meaning of the art project of the top manager of the UMMC Maria Osipova. The methodological basis for analysis is the concept of a book of poems as a complex artistic unity that implements a single plan and ...
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Real-time sensor networks based on genetic algorithms application in the analysis of innovative data in cultural industry management

Measurement: Sensors
Against the backdrop of sustained economic development and steady improvement of China's overall national strength, the cultural industry is in a good stage of development, but it also faces problems such as data complexity and difficulty in organizing ...
Baohui Zhang, Zaixi Yang, Jinqing Zhang, Qingqing Xu   +3 more
doaj   +1 more source

Alcohol and other drugs in the Australian construction industry: a pathway for safety focused cultural change [PDF]

, 2013
Background: Anecdotal evidence from the infrastructure and building sectors highlights issues of alcohol and other drugs (AODs) and its association with safety risk on construction sites.
Biggs, Herbert, Williamson, Amy
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A Systematic Review of Contemporary Challenges and Debates on Chinese Food Security: Integrating Priorities, Trade-Offs, and Policy Pathways

Foods
Although food security has been a long-standing focus of research and policy in China, significant gaps remain in synthesizing evolving debates across multiple disciplines such as agriculture, economics, environmental science, and politics.
Rong Zeng, Meseret C. Abate, Baozhong Cai, Amsalu K. Addis, Yonas Derebe Dereso   +4 more
doaj   +1 more source