Results 71 to 80 of about 21,166 (263)

RESEARCHES OF THE YOUTH PERSPECTIVE IN MODERN RUSSIA: RECEPTION OF FOREIGN THEORETICAL-CONCEPTUAL APPROACHES

Вестник Кемеровского государственного университета, 2015
The paper acquaints the reader with the Russian and foreign authors’ researches concerning the position and role of the youth in the political structure.
A. A. Mitin
doaj  

Socio-economic and cultural aspects of E-sports: A literature review [PDF]

Ekonomski Signali
E-sports have, over the past decade, evolved into one of the most dynamic phenomena of digital culture, with significant economic, social, and cultural implications.
Dašić Dejan
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Makna Simbolik Stiker WhatsApp dan Normalisasi Humor Seksual di Era Generasi Zilenial

Jurnal Sosial Humaniora
The rapid development of digital communication has increased the use of WhatsApp stickers as a dominant expressive medium, particularly among Generation Z.
Deha D. Lilian Putri, Nisrina Azka Putri, Revio Xamanda Miyugi, Bernard Agung Barto Ramba, Adela Salsabila C.P, Abdurrahman Faishal   +5 more
doaj   +2 more sources

Spatiotemporal Evolutionary Mechanisms of Gardens on Hainan Island from the Tang to the Qing Dynasties

Land
The spatial distribution patterns and temporal evolution of ancient designed gardens provide critical insights into the interactive dynamics among regional human–environment relationships, institutional structures, and cultural transmission.
Xiaocui Feng, Zuoyuan Zhang, Guangsi Lin, Shuling Li, Guangzhen Lin   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Normalizacja innowacyjności w szkole – normy kulturowe jako determinanty potencjału innowacyjnego nauczycieli

Problemy Wczesnej Edukacji
The article attempts to analyze the issue of innovation from a cultural perspective in relation to teachers’ teams as one of the subcultures in the school’s organizational culture. Culture may facilitate or hinder the assimilation of innovations.
Małgorzata Joanna Karwasz
doaj   +1 more source