Results 81 to 90 of about 138,952 (282)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Privacy, Visibility, Transparency, and Exposure [PDF]

, 2008
This essay considers the relationship between privacy and visibility in the networked information age. Visibility is an important determinant of harm to privacy, but a persistent tendency to conceptualize privacy harms and expectations in terms of ...
Cohen, Julie E.
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Governance of Cultural Diversities in Spain Linguistic, Religious and Artistic Diversity in Two Autonomous Spanish Communities

Fédéralisme-Régionalisme, 2015
This chapter examines how the Spanish state and two autonomous communities (the Basque Autonomous Community and Galicia) have addressed linguistic, religious, and artistic diversity.
Mónica Ibáñez Angulo
doaj  

Socio-economic and cultural aspects of E-sports: A literature review [PDF]

Ekonomski Signali
E-sports have, over the past decade, evolved into one of the most dynamic phenomena of digital culture, with significant economic, social, and cultural implications.
Dašić Dejan
doaj   +1 more source

On the Perturbation of Self-Organized Urban Street Networks

, 2019
We investigate urban street networks as a whole within the frameworks of information physics and statistical physics. Urban street networks are envisaged as evolving social systems subject to a Boltzmann-mesoscopic entropy conservation.
Benoit, Jerome, Jabari, Saif Eddin
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Pesantren Intellectual Activism Outside of Islam and Muslims: Study of the Jalan Dakwah Pesantren (2016) Documentary Film

Kalijaga Journal of Communication
This research tries to reexamine the meaning of Pesantren (Islamic boarding schools) as inclusive spaces by reinterpreting the film Jalan Dakwah Pesantren (2016).
Ahmad Afrizal Qosim, Istifadah Nur Rahma
doaj   +1 more source

Digitally Archiving Architectural Models and Exhibition Designs: The Case of an Art Museum [PDF]

, 2015
[Excerpt] In 2013, a medium-sized art museum located in the Northeast United States received a grant to plan for an electronic records repository. This museum will be referred to here as USAM for brevity.
Cocciolo, Anthony
core   +1 more source