Results 11 to 20 of about 311,436 (256)

Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

open access: yesOsteoarthritis and Cartilage Open, 2021
Objective: To gain insight into Treg interactions with synovial tissues in early OA, an equine tri-culture model of OA was used to test the hypothesis that Tregs, in the absence of T Helper 17 ​cells, are sufficient to resolve inflammation elicited by IL-
Laura E. Keller   +3 more
doaj   +1 more source

The Effects of Static and Dynamic Culture Systems on Cell Proliferation and Conditioned Media of Umbilical Cord-derived Mesenchymal Stem Cells

open access: yesInternational Journal of Technology, 2021
Preclinical and clinical studies have demonstrated the therapeutic effects of umbilical cord-derived mesenchymal stem cells (UC-MSCs) and secretome to cure various degenerative diseases.
Retno Wahyu Nurhayati   +6 more
doaj   +1 more source

The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes

open access: yesPediatric Rheumatology Online Journal, 2021
Background We examined influences of conditioned media from chondrocytes (Ch) on juvenile idiopathic arthritis synovial fibroblasts (JFLS) and potential for JFLS to undergo endochondral bone formation (EBF).
Megan M. Simonds   +5 more
doaj   +1 more source

Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell [PDF]

open access: yesDiabetes & Metabolism Journal, 2021
Background Umbilical cord-mesenchymal stem cell-conditioned medium (UC-MSC-CM) has emerged as a promising cell-free therapy. The aim of this study was to explore the therapeutic effects of UC-MSC-CM on insulin resistance in C2C12 cell.
Kyung-Soo Kim   +8 more
doaj   +1 more source

Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]

open access: yes, 2020
Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A.   +2 more
core   +1 more source

The Role of Trophoblastic Stem Cells Conditioned Media on JAR Cell Culture

open access: yesProceedings, 2017
Trophoblasts are placenta-specific epithelial cells which play an important role in embryo implantation. Trophoblast stem cells (TSCs) are precursor cells of placenta and can be derived before or after implantation. During TSCs culture, several molecules
Hilal Kabadayı   +2 more
doaj   +1 more source

Selectivity of direct plasma treatment and plasma-conditioned media in bone cancer cell lines

open access: yesScientific Reports, 2021
Atmospheric pressure plasma jets have been shown to impact several cancer cell lines, both in vitro and in vivo. These effects are based on the biochemistry of the reactive oxygen and nitrogen species generated by plasmas in physiological liquids ...
Inès Hamouda   +4 more
doaj   +1 more source

MESENCHYMAL STEM CELLS: EXOSOMES AND CONDITIONED MEDIA AS INNOVATIVE STRATEGIES IN THE TREATMENT OF PATIENTS WITH AUTOIMMUNE DISEASES

open access: yesКлінічна та профілактична медицина, 2023
Introduction. Autoimmune diseases are a class of immunopathological conditions heterogeneous in clinical manifestations, characterized by immune disorders that cause the loss of the body's autoimmune tolerance and, as a result, abnormal reactivity of B ...
Fedir V. Hladkykh
doaj   +1 more source

IL-1 beta and TNF alpha Promote Monocyte Viability through the Induction of GM-CSF Expression by Rheumatoid Arthritis Synovial Fibroblasts [PDF]

open access: yes, 2014
Background. Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). SF could be a source of cytokines and growth factors driving macrophages survival and activation.
Blanchard, F.   +6 more
core   +4 more sources

Increasing angiogenic efficacy of conditioned medium using light stimulation of human adipose-derived stem cells

open access: yesCommunications Biology, 2022
Combining spheroidal culture of human adipose-derived stem cells with light irradiation enhances angiogenic growth factor secretion in conditioned media, which can improve angiogenesis in a mouse hindlimb ischemia model.
Yu-Jin Kim   +5 more
doaj   +1 more source

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