Results 31 to 40 of about 3,578,819 (354)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Research and Pedagogy in Intercultural New Media Studies [PDF]
, 2012 New media are ubiquitous, changing the landscape of intercultural communication. Intercultural new media studies (INMS), first introduced and conceptualized by Robert Shuter in 2012 in his article in the Journal of Intercultural Communication Research ...
Shuter, Robert
core +1 more source
Media and Power After Stuart Hall [PDF]
, 2016 In commemorating Stuart Hall, I wish to pay particular attention to the importance of his work for understanding one of the great topics of contemporary culture— media.There is a long discussion to be had of Stuart Hall’s making and use of media, in ...
Goggin, Gerard
core +3 more sources
Vaccine: X, 2019 In recent years, vaccination rates in the Netherlands have declined slightly, but steadily. The Dutch National Institute for Public Health and the Environment (RIVM) commissioned a Committee for Vaccine Willingness (VWC) to study the societal context of ...
Roel O. Lutkenhaus +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
The Journal of Chinese SociologyWhy do some people opt for exergames like Ring Fit Adventure (RFA) over traditional exercise venues such as gyms? Focusing on the case of RFA, this study examines the social factors that contribute to this preference and explores the potential of video ...
Jiangwei Zhou, Yu Zhao
doaj +1 more source
Singing and Social Identity in Young Children
Frontiers in Psychology, 2022 A range of studies suggest that singing activities with young children can have a beneficial impact on other aspects of their development. However, there is little research examining the relationship between young children's singing and their developing ...
Ioulia Papageorgi +3 more
doaj +1 more source
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
core +1 more source