Results 31 to 40 of about 1,080,305 (313)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interactive Multimodal Television Media Adaptive Visual Communication Based on Clustering Algorithm

Complexity, 2020
This article starts with the environmental changes in human cognition, analyzes the virtual as the main feature of visual perception under digital technology, and explores the transition from passive to active human cognitive activities.
Huayuan Yang, Xin Zhang
doaj   +1 more source

Evaluating the impact of open access policies on research institutions

eLife, 2020
The proportion of research outputs published in open access journals or made available on other freely-accessible platforms has increased over the past two decades, driven largely by funder mandates, institutional policies, grass-roots advocacy, and ...
Chun-Kai (Karl) Huang, Cameron Neylon, Richard Hosking, Lucy Montgomery, Katie S Wilson, Alkim Ozaygen, Chloe Brookes-Kenworthy   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Big AI: Cloud infrastructure dependence and the industrialisation of artificial intelligence

Big Data & Society
Critical scholars contend that ‘There is no AI without Big Tech’. This study delves into the substantial role played by major technology conglomerates, including Amazon, Microsoft, and Google (Alphabet), in the ‘industrialisation of artificial ...
Fernando van der Vlist, Anne Helmond, Fabian Ferrari   +2 more
doaj   +1 more source

Binge-Watching Netflix? Insights From Data Donations

Media and Communication
Netflix is often credited with mainstreaming binge-watching through its release strategy and interface features. However, despite this reputation, data on actual consumption patterns remains scarce, enabling Netflix to shape the narrative about how ...
Karin van Es, Dennis Nguyen
doaj   +1 more source

"Within the hour" and "wherever you are": Exploring the promises of digital healthcare apps

Journal of Digital Social Research, 2021
The use of healthcare apps for medical advice is becoming increasingly common. This paper explores apps that offer interaction with medical experts.
Anna Sofia Lundgren, Jens Lindberg, Eric Carlsson   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

South African Media and Politics: Is the Three Models Approach Still Valid After Two Decades?

Media and Communication
When Hallin and Mancini (2004) produced their watershed three models theory, South Africa was a new democracy barely a decade old. Even then, along with other countries of the Global South, the experience of a young democracy posed certain critical ...
Bernadine Jones, Adrian Hadland
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source