Results 41 to 50 of about 3,512,085 (357)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

An improved medium formulation for efficient ex vivo gene editing, expansion and engraftment of hematopoietic stem and progenitor cells

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
Gene editing has emerged as a powerful tool for the therapeutic correction of monogenic diseases. CRISPR-Cas9 applied to hematopoietic stem and progenitor cells (HSPCs) has shown great promise in proof-of-principle preclinical studies to treat ...
Rajeev Rai   +6 more
doaj  

RESPONSES OF SOME NEW ROMANIAN POTATO VARIETIES TO THE IN VITRO HIDRIC STRESS

open access: yesAgricultura, 2021
Plant performance and crop yield are negatively affected by drought and heat in the context of the global climate changes. The present study was carried out to the National Institute for Research and Development Brasov, Romania, to observe the ...
Manuela Hermeziu   +2 more
doaj   +1 more source

Friables and embryogenic callus induction from embryo, ovule and style of citrus rootstocks : [P97] [PDF]

open access: yes, 2008
The incorporation of new technologies such as in vitro selection and protoplast fusion methods into citrus improvement programs offers new opportunities to facilitate, expedite, and fully utilize germplasm variability for both scion and rootstock ...
Arsalan, N.   +6 more
core  

Bta-miR-10b secreted by bovine embryos negatively impacts preimplantation embryo quality [PDF]

open access: yes, 2019
In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake results
Deforce, Dieter   +6 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Treatment with conditioned culture media with human mesenchymal stem cells on reserpine-induced thermal fibromyalgia model in rats

open access: yesمجله دانشگاه علوم پزشکی بیرجند, 2022
Background and Aims: Fibromyalgia (FM) is a chronic pain syndrome affected by the hippocampal function. Mesenchymal stem cells-conditioned medium (MSC-CMs) has shown antioxidant and neuroprotective potentials in treating various diseases.
Farzaneh Jasbinia   +1 more
doaj  

An exploratory study of mechanisms to transfer and embed a value-based culture : A thesis presented in partial fulfilment of the requirements for the degree of Masters of Business Studies in Management at Massey University, Auckland, New Zealand [PDF]

open access: yes, 2016
This exploratory study seeks to build on the work of theorists who have proposed concepts to enhance organisational culture through a better alignment of values.
Wallace, Andrew Mark
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

FIBRIN AND SERUM AS A CULTURE MEDIUM [PDF]

open access: yesJournal of Experimental Medicine, 1921
A technique is described by which a medium composed of fibrinogen suspension, serum, and embryo juice may be made. Fibroblasts grew in this medium about as well as in plasma and embryo juice. A strain of connective tissue in this medium remained practically as active as the control for several passages.
openaire   +3 more sources

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