Results 61 to 70 of about 19,711 (263)

Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle

Reproductive Biology and Endocrinology, 2006
Background The objective of this study was to investigate whether the steroid hormone(s) secreted from cumulus-oocyte complexes (COCs) is a prerequisite for bovine oocyte maturation and cumulus expansion using aminoglutethimide (AGT), a P450 cholesterol ...
Yamashita Yasuhisa, Yamashiro Hideaki, Kumamoto Kanako, Isobe Naoki, Wang Hai, Terada Takato   +5 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Competência oocitária: importância e fatores determinantes in vivo e in vitro

Medicina Veterinária, 2019
As biotécnicas reprodutivas impulsionaram a pecuária no cenário do agronegócio mundial em virtude da redução do intervalo entre gerações, acelerado ganho genético e intensificação da produtividade. Nesse âmbito, existem, no entanto, desafios biológicos e
Letícia Ferrari Crocomo, Fernanda da Cruz Landim-Alvarenga, Sony Dimas Bicudo   +2 more
doaj  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Distinct Mixing Regimes in Shallow Cumulus Clouds

Geophysical Research Letters
Understanding the nature of mixing between cloudy air and its surroundings is an important and yet, open question. In this research, we use high‐resolution (10 m) bin‐microphysics Large Eddy Simulation of a cumulus cloud, together with a Lagrangian ...
Yael Arieli, Eshkol Eytan, Orit Altaratz, Alexander Khain, Ilan Koren   +4 more
doaj   +1 more source

BMP15 Prevents Cumulus Cell Apoptosis Through CCL2 and FBN1 in Porcine Ovaries

Cellular Physiology and Biochemistry, 2013
Background: Bone morphogenetic protein-15 (BMP15) is a maternal gene necessary for mammalian reproduction. BMP15 expression increased in oocytes accompanied by follicle growth and development.
Bo Zhai, Huiyu Liu, Xu Li, Lisheng Dai, Yan Gao, Changhong Li, Lianjiang Zhang, Yu Ding, Xianfeng Yu, Jiabao Zhang   +9 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

A First Look at the Global Climatology of Low‐Level Clouds in Storm Resolving Models

Journal of Advances in Modeling Earth Systems
The representation of subtropical stratocumulus and trade‐wind cumulus clouds by preliminary versions of Integrated Forecasting System (IFS) and ICON km‐scale global coupled climate models is explored.
Jakub L. Nowak, Ian C. D. V. Dragaud, Junhong Lee, Piotr Dziekan, Juan Pedro Mellado, Bjorn Stevens   +5 more
doaj   +1 more source

Effect of presence of corpora lutea on cumulus expansion of in vitro matured bovine oocytes selected by trypan blue and brilliant cresyl blue tests

Journal of Applied Animal Research, 2018
Trypan Blue (TB) and Brilliant Cresyl Blue (BCB) are used to select and determine viability and competence of oocytes, however, the effects of corpora lutea on cumulus expansion during in vitro maturation are still undetermined. Cumulus-oocytes complexes
Andrés Quezada-Casasola, Karla Eugenia Martínez-Armendáriz, Mateo Fabián Itzá-Ortiz, Angélica María Escárcega-Ávila, Eduardo Pérez-Eguía, Yael Filipiak, Clara Larocca, José María Carrera-Chávez   +7 more
doaj   +1 more source