Results 41 to 50 of about 19,711 (263)

Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation

Journal of Ovarian Research, 2023
Bi-directional communication between cumulus cells and the surrounded oocytes is important for the development and functions of both compartments. However, the metabolic framework in cumulus cells has not been systematically described.
Ming Chen, Weizheng Yang, Yueshuai Guo, Xiaojing Hou, Shuai Zhu, Hongzheng Sun, Xuejiang Guo, Minjian Chen, Qiang Wang   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Investigating the Periphery Region in Warm Cumulus Clouds

Geophysical Research Letters
Warm cumulus clouds are key components of Earth's weather and climate systems, yet mixing processes within them and their interaction with their environment remain a major source of uncertainty in climate predictions.
Yael Arieli, Orit Altaratz, Alexander Khain, Ilan Koren   +3 more
doaj   +1 more source

DNA damage in cumulus cells generated after the vitrification of in vitro matured porcine oocytes and its impact on fertilization and embryo development

Porcine Health Management, 2021
Background The evaluation of the DNA damage generated in cumulus cells after mature cumulus-oocyte complexes vitrification can be considered as an indicator of oocyte quality since these cells play important roles in oocyte developmental competence ...
Alma López, Miguel Betancourt, Yvonne Ducolomb, Juan José Rodríguez, Eduardo Casas, Edmundo Bonilla, Iván Bahena, Socorro Retana-Márquez, Lizbeth Juárez-Rojas, Fahiel Casillas   +9 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

An Ensemble Sensitivity Analysis for Optimizing Physical Schemes in Summer Heavy Rainfall Predictions Over DPR Korea

Meteorological Applications
Extreme summer rainfall events pose a major hydrological hazard in the Democratic People's Republic of Korea (DPRK), where majority of annual heavy precipitation occurs during the July–August monsoon season.
Kum‐Ryong Jo, Song‐In Pak, Hyok‐Chol Kim, Chang‐Bok Rim, Song‐Hak Nam, Won‐Sok Hong   +5 more
doaj   +1 more source

Dual effects of hydrogen sulfide donor on meiosis and cumulus expansion of porcine cumulus-oocyte complexes. [PDF]

PLoS ONE, 2014
Hydrogen sulfide (H2S) has been revealed to be a signal molecule with second messenger action in the somatic cells of many tissues, including the reproductive tract. The aim of this study was to address how exogenous H2S acts on the meiotic maturation of
Jan Nevoral, Jaroslav Petr, Armance Gelaude, Jean-Francois Bodart, Veronika Kucerova-Chrpova, Marketa Sedmikova, Tereza Krejcova, Tereza Kolbabova, Marketa Dvorakova, Alena Vyskocilova, Ivona Weingartova, Lenka Krivohlavkova, Tereza Zalmanova, Frantisek Jilek   +13 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source