Results 51 to 60 of about 16,687 (259)

Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes [PDF]

Journal of Cell Science, 2016
Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial for producing fertilizable oocytes competent to support embryogenesis. However, how oocyte-derived signaling regulates these essential processes remains largely undefined.
Jing Guo, Lanying Shi, Xuhong Gong, Mengjie Jiang, Yaoxue Yin, Xiaoyun Zhang, Hong Yin, Hui Li, Chihiro Emori, Koji Sugiura, John J. Eppig, You-Qiang Su   +11 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Malonic acid promotes glycolytic activity in cumulus cells and improves the quality of bovine oocytes matured in vitro

The Journal of Reproduction and Development
Malonic acid (MA) is a dicarboxylic acid that inhibits the mitochondrial electron transport chain. Cumulus cells surrounding human oocytes that achieve conception after in vitro fertilization (IVF) contain higher levels of MA ...
Nobuhiko ITAMI, Yuji HIRAO
doaj   +1 more source

In Vitro Stimulation of Cumulus-Cell Expansion by Human Cord Serum in Mouse Oocyte–Cumulus Complexes [PDF]

Journal of Assisted Reproduction and Genetics, 1998
The aim of this study was to test whether human cord serum (HCS) containing gonadotropins has an effect on the expansion of oocyte-cumulus complexes (OCCs).The concentration of follicle stimulating hormone (FSH) and luteinizing hormone (LH) was measured in HCS by radioimmunoassay (RIA).
Y I, Lee, H J, Park, Y S, Kwon
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Chenodeoxycholic acid improves oocyte maturation and embryo quality during bisphenol A exposure by activating the EGFR-ERK1/2 signaling pathway

Ecotoxicology and Environmental Safety
Chenodeoxycholic acid (CDCA) is a free bile acid present in the follicular fluid surrounding growing oocytes. In this study, we demonstrate that supplementation with CDCA activates the EGFR signaling in cumulus-oocyte complexes (COCs) to improve oocyte ...
Zhi-Yong An, Tuo Zhang, Gao-Jie Lu, Xiaoyufan Xu, Xue Fang, Sheng-Zhong Han, Shuang-Yan Chang, Xi-Jun Yin, Lin-Hu Quan, Jin-Dan Kang   +9 more
doaj   +1 more source

Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ADAM17 gene expression during in vitro maturation of porcine COCs

Journal of Ovarian Research, 2009
Objectives During ovulation, it has been shown that LH stimulus induces the expression of numerous genes via PKA, p38 MAPK, PI3K and ERK1/2 in cumulus cells and granulosa cells.
Yamashita Yasuhisa, Hishinuma Mitsugu, Shimada Masayuki   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Cumulus cell DNA damage linked to fertilization success in females with an ovulatory dysfunction phenotype

Frontiers in Cell and Developmental Biology
Intracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte competence. However,
Bárbara Rodrigues, Bárbara Rodrigues, Bárbara Rodrigues, Vanessa Sousa, Vanessa Sousa, Vanessa Sousa, Filipa Esteves, Filipa Esteves, Filipa Esteves, Emídio Vale-Fernandes, Emídio Vale-Fernandes, Emídio Vale-Fernandes, Solange Costa, Solange Costa, Solange Costa, Daniela Sousa, Raquel Brandão, Carla Leal, Joana Pires, Joana Pires, Joana Pires, Isabel Gaivão, João Paulo Teixeira, João Paulo Teixeira, João Paulo Teixeira, António J. A. Nogueira, Paula Jorge, Paula Jorge, Paula Jorge   +28 more
doaj   +1 more source