Results 111 to 120 of about 9,893 (241)

Photometric detection in flow analysis systems using integrated PEDDs [PDF]

, 2005
A novel inexpensive optical-sensing technique has been developed for colorimetric flow analysis. This sensing system employs two LEDs whereby one is used as the light source and the other as a light detector.
Diamond, Dermot, Lau, King-Tong, O'Toole, Martina   +2 more
core   +2 more sources

Attenuating the experimental autoimmune encephalomyelitis model improves preclinical evaluation of candidate multiple sclerosis therapeutics

Animal Models and Experimental Medicine, Volume 8, Issue 8, Page 1428-1440, August 2025.
This graphical abstract presents a summary of the research conducted in our laboratory. Our goal was to optimize the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), which is typically highly aggressive, to enhance its use in therapeutic drug trials.
Vernise J. T. Lim, Melanie J. Murphy, W. Stephen Penrose, Coral Warr, M. Cristina Keightley, Jacqueline M. Orian   +5 more
wiley   +1 more source

Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model

Mediators of Inflammation, 2013
We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice.
Catarina Raposo, Ana Karolina de Santana Nunes, Rayana Leal de Almeida Luna, Shyrlene Meiry da Rocha Araújo, Maria Alice da Cruz-Höfling, Christina Alves Peixoto   +5 more
doaj   +1 more source

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Cell Reports, 2020
Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival.
Martha S. Windrem, Steven J. Schanz, Lisa Zou, Devin Chandler-Militello, Nicholas J. Kuypers, Maiken Nedergaard, Yuan Lu, John N. Mariani, Steven A. Goldman   +8 more
doaj   +1 more source

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. [PDF]

, 2014
Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell differentiation and migration in the periphery, but
Bannerman, Peter, Burns, Travis, Guo, Fuzheng, Ko, David, Lee, Eunyoung, Ma, Joyce H, Miers, Laird, Mills Ko, Emily, Pleasure, David, Sohn, Jiho, Soulika, Athena M   +10 more
core   +3 more sources

Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS [PDF]

, 2017
Background Laquinimod is an oral immunomodulator in clinical development to treat relapsing-remitting multiple sclerosis (RRMS). Laquinimod is in clinical development for the treatment of multiple sclerosis and Huntington Disease (HD).
Paul, Friedemann, Richter, Nils, Samara, Emil, Sehr, Tony, Spiegelstein, Ofer [u.a.], Thomas, Katja, Tumani, Hayrettin, Ziemssen, Tjalf   +7 more
core   +1 more source

Antiaris africana aqueous extract inhibits chronic demyelination and seizures in mice

Heliyon
Demyelinating diseases are commonly associated with epileptic seizures and have limited management options. Hence, the need to investigate potential options for management of such seizures.
Ransford Amoah, John Danquah, Priscilla Kolibea Mante   +2 more
doaj   +1 more source

Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

Frontiers in Pharmacology, 2019
Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features that contribute to the mood swing and cognitive decline in major depressive disorder (MDD) and multiple sclerosis (MS).
Yanbo Zhang, Xiaoying Bi, Olubunmi Adebiyi, Junhui Wang, Ali Mooshekhian, Jacob Cohen, Zelan Wei, Fei Wang, Xin-Min Li   +8 more
doaj   +1 more source

CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5

, 2021
Kyle S. Saitta, Lauren D. Lercher, Danielle M. Sainato, Ashish Patel, Yangyang Huang, Geoffrey McAuliffe, Cheryl F. Dreyfus   +6 more
openalex   +2 more sources

Protective effects of cannabidiol on cuprizone-induced demyelination in C57BL/6 mice

Journal of Contemporary Medical Sciences, 2017
Objective Experimental and clinical studies suggest that oxidative stress plays an important role in the pathogenesis of multiple sclerosis. In this study, we have investigated the effects of the non-psychoactive cannabinoid cannabidiol (CBD), which ...
Maryam Sajjadian, Iraj Ragerdi Kashani, Parichehr Pasbakhsh, Mahmoud Hassani, Ameneh Omidi, Nasrin Takzare, Tim Clarner, Cordian Beyer, Adib Zendedel   +8 more
doaj