Results 121 to 130 of about 9,893 (241)

Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. [PDF]

, 2013
BackgroundTherapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases.
Hannsun, Gemmy, Hayardeny, Liat, Khalaj, Anna J, Martinez-Torres, Leonardo, Moore, Spencer, Patel, Rhusheet, Sasidhar, Manda, Tiwari-Woodruff, Seema K, Yoo, Timothy, Yoon, Jaehee   +9 more
core  

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system [PDF]

, 2017
The IκB kinase complex induces nuclear factor kappa B activation and has recently been recognized as a key player of autoimmunity in the central nervous system.
Bethea, John R., Blank, Thomas, Brück, Wolfgang, Del Turco, Domenico, Deller, Thomas, Erny, Daniel, Knobeloch, Klaus-Peter, Knust, Markus, Merkler, Doron, Mildner, Alexander, Pasparakis, Manolis, Priller, Josef, Prinz, Marco, Raasch, Jenni, van Loo, Geert, Waisman, Ari, Zeller, Nicolas   +16 more
core  

The effects of combined administration of human umbilical cord-derived multipotent mesenchymal stromal cells and melatonin or fibroblast growth factor-2 to aged mice with a toxic cuprizone model of demyelination [PDF]

, 2021
І. F. Labunets, N. Utko, O. K. Toporova, Ianina Pokholenko, T.N. Panteleymonova, Z. Litoshenko, G. M. Butenko   +6 more
openalex   +1 more source

The demyelinating agent cuprizone induces a male-specific reduction in binge eating in the binge-prone C57BL/6NJ strain [PDF]

, 2019
R.K. Babbs, Jacob A. Beierle, Julia C. Kelliher, Rose Anne Medeiros, Jeya Anandakumar, Anyaa A. Shah, Emily J. Yao, Melanie M. Chen, Camron D. Bryant   +8 more
openalex   +1 more source

The Protective Effects ofAreca catechuExtract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model [PDF]

, 2015
Abulimiti Adilijiang, Teng Guan, Jue He, Kelly Hartle, Wenqiang Wang, Xin‐Min Li   +5 more
openalex   +1 more source

Defective fractalkine‐CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone‐induced demyelination

, 2022
Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy B. Macklin, Sérgio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin‐Hsing Annie Lin, Astrid E. Cardona   +10 more
openalex   +2 more sources

Cuprizone intoxication perturbs central nervous system metabolism

, 2016
Cuprizone intoxication is a common animal model used to test new myelin regenerative therapies for diseases such as multiple sclerosis. Mice fed this copper chelator develop reversible, region-specific oligodendrocyte loss and demyelination.  While the cellular correlates influencing myelin have been well studied in this model, there
Taraboletti, Alexandra, Huang, He, Shriver, Leah   +2 more
openaire   +1 more source

TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model

, 2021
H.A. Iocca, S.R. Plant, Y. Wang, L. Runkel, B.P. O apos Connor, E.T. Lundsmith, K. Hahm, H.W. van Deventer, L.C. Burkly, J.P.-Y. Ting   +9 more
openalex   +1 more source

Modeling multiple sclerosis in laboratory animals [PDF]

, 2018
Inflammatory demyelinating disease of the central nervous system is one of the most frequent causes of neurological disability in young adults. While in situ analysis and in vitro models do shed some light onto the processes of tissue damage and cellular
Becher, Burkhard, Heppner, Frank, Schreiner, Bettina   +2 more
core  

Evaluation of the cuprizone model [PDF]

, 2022
openaire   +1 more source