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The Cuprizone Mouse Model: A Comparative Study of Cuprizone Formulations from Different Manufacturers [PDF]
International Journal of Molecular Sciences, 2023 The Cuprizone mouse model is widely used in studies on de- and remyelination. In the hands of different experimenters, the Cuprizone concentrations that lead to comparable levels of demyelination differ considerably. The reasons for this variability are unknown.
Markus Kipp +2 more
exaly +5 more sources
Cuprizone neurotoxicity, copper deficiency and neurodegeneration [PDF]
NeuroToxicology, 2010 Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative disorders such as severe status spongiosus. Although it has a simple chemical formula, its neurotoxic mechanism is still unknown. In this work, we examined both physico-chemical properties and biological effects of cuprizone. Our
Paola D'Angelo +2 more
exaly +8 more sources
The Cuprizone Model: Dos and Do Nots [PDF]
Cells, 2020 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options.
Markus Kipp +2 more
exaly +6 more sources
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The cuprizone model for demyelination
Acta Neurologica Scandinavica, 2008Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination.
K-M Myhr
exaly +3 more sources
Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis [PDF]
Neuroscience and Biobehavioral Reviews, 2014 The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination.
Peter Ponsaerts +2 more
exaly +2 more sources
CD44 expression in the cuprizone model
Brain Research, 2020Numerous studies report that changes in extracellular matrix components and receptors, such as CD44, contribute to immune cell recruitment and thus lesion formation in multiple sclerosis (MS). In the present study, we used the cuprizone model to elucidate the expression pattern of CD44 in a toxin-induced MS model.
Christin Reinbach +6 more
openaire +2 more sources
Investigation of Cuprizone Inactivation by Temperature
Neurotoxicity Research, 2017Animal models, such as cuprizone (bis-cyclohexanone oxaldihydrazone) feeding, are helpful to study experimental demyelination and remyelination in the context of diseases like multiple sclerosis. Cuprizone is a copper chelator, which when supplemented to the normal food of C57BL/6J mice in a concentration of 0.2% leads to oligodendroglial loss ...
Sandra, Heckers +6 more
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Variation in the Response of Mice to Cuprizone
Research in Veterinary Science, 1973Summary Weanling mice from 2 populations were fed 1% cuprizone for 59 days. During the experiment an assessment was made of the body weight and clinical condition of these mice and equivalent controls. The weight gain and behaviour of the control mice were similar throughout.
S, Elsworth, J M, Howell
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Synthesis and structural characterization of copper–cuprizone complexes
Dalton Transactions, 2022The chemistry of copper with cuprizone has challenged chemists for over 70 years. We characterize the classical ‘blue’ product, containing Cu(iii) and hydrolyzed cuprizone, and a green multimeric Cu(ii) product, containing unhydrolyzed cuprizone.
M. Jake Pushie +4 more
openaire +2 more sources