Results 161 to 170 of about 5,891 (192)

Ultrastructural changes of cuprizone encephalopathy in mice

Toxicology and Applied Pharmacology, 1971
Abstract The ultrastructural features of the encephalopathy induced by chronic feeding of cuprizone in the white matter of the cerebellar medulla of mice were characterized. Mice were fed a diet of 0.5% cuprizone for 8 wk and, under anesthesia, were perfused with 6% buffered glutaraldehyde.
R D, Hemm, W W, Carlton, J R, Welser
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Demyelination of the hippocampus is prominent in the cuprizone model

Neuroscience Letters, 2009
In multiple sclerosis demyelination not only affects the white matter, but also the grey matter of the brain. We have previously reported that in the murine cuprizone model for demyelination lesions occur in addition to the corpus callosum also in the neocortex and hippocampus. In the current study, we provide a detailed characterization of hippocampal
Paraskevi N, Koutsoudaki, Thomas, Skripuletz, Viktoria, Gudi, Darius, Moharregh-Khiabani, Herbert, Hildebrandt, Corinna, Trebst, Martin, Stangel   +6 more
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Behavioural and histological changes in cuprizone-fed mice

Brain, Behavior, and Immunity, 2020
Feeding cuprizone (CPZ) to mice causes demyelination and reactive gliosis in the central nervous system (CNS), hallmarks of some neurodegenerative diseases like multiple sclerosis. However, relatively little is known regarding the behavioural deficits associated with CPZ-feeding and much of what is known is contradictory.
Sen, Monokesh (R19837), Almuslehi, Mohammed S. (S32978), Coorssen, Jens R., Mahns, David A. (R11697), Shortland, Peter J. (R17436)   +4 more
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The cuprizone model: regional heterogeneity of pathology

APMIS, 2012
The cuprizone model is a model of de‐ and remyelination secondary to oligodendrocyte death, likely to be mediated by an inhibition of mitochondrial function. The aim of this study was to characterize histopathological changes associated with de/remyelination in grey and white matter at different disease stages in C57Bl/6 mice after per oral ...
Stig, Wergeland, Øivind, Torkildsen, Kjell-Morten, Myhr, Sverre Jarl, Mørk, Lars, Bø   +4 more
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Cuprizone

2000
Abstract Cuprizone is a disubstituted hydrazine with a MP of 214°-2160C. It is a copper chelator and has been used in a quan titative spectrophotometric procedure for copper analysis (17). In a study of an animal model of swayback (a copper deficiency disease of sheep and calves), cuprizone caused hydrocephalus, spongiform change ...
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Cuprizone toxicosis in mice—Attempts to antidote the toxicity

Toxicology and Applied Pharmacology, 1972
Abstract Studies were undertaken to evaluate the effects of glutamic acid, glutamine, arginine, pyridoxine, γ-aminobutyric acid (GABA) and glucose on the cuprizone-induced toxicosis and encephalopathy in Swiss albino mice. Cuprizone was fed for 8 wk at dietary concentrations of 0.3, 0.5 and 0.75%.
J W, Kesterson, W W, Carlton
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Cuprizone neurotoxicity in the rat: Morphologic observations

Journal of the Neurological Sciences, 1988
Weanling male Wistar rats fed a diet containing 0.5-2% cuprizone developed intramyelinic edema of the cerebellar white matter, hilum of the dentate nucleus and superior cerebellar peduncle. Oligodendrocytes in these regions showed hyperchromatic nuclei and abnormally dense cytoplasm, with an increase in the number of free ribosomes and enlargement of ...
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Cuprizone as a model of myelin and axonal damage

Drug Discovery Today: Disease Models, 2017
Axonal damage is believed to be the main factor contributing to disease progression in multiple sclerosis patients. The degeneration of axons could be the result of several different harmful events including inflammation and demyelination. Details of the mechanisms leading to axonal damage are, however, unknown, and distinct preclinical animal models ...
Stella Nyamoya, Felix Schweiger, Markus Kipp, Tanja Hochstrasser   +3 more
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The effects of cuprizone toxicity on the incubation period of scrapie in mice

Journal of Comparative Pathology, 1976
Abstract Relatively short periods of cuprizone toxicity were induced in mice at selected times in the incubation period of “Chandler” scrapie. Toxicity induced at the time of i.c. and i.p. infection produced effects on the length of incubation period and on the number of mice surviving low doses of scrapie agent.
R H, Kimberlin, G C, Millson
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Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus

Journal of Neuroscience Research, 2008
AbstractMemory impairment is outstanding within the spectrum of cognitive deficits in multiple sclerosis (MS) patients. Demyelination has been reported in the hippocampus formation of MS patients. The degree of hippocampus lesions in MS strongly correlates with progression of cognitive dysfunction.
Akvile, Norkute, Andrea, Hieble, Alena, Braun, Sonja, Johann, Tim, Clarner, Werner, Baumgartner, Cordian, Beyer, Markus, Kipp   +7 more
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