Results 181 to 190 of about 8,969 (212)

Behavioural and histological changes in cuprizone-fed mice

Brain, Behavior, and Immunity, 2020
Feeding cuprizone (CPZ) to mice causes demyelination and reactive gliosis in the central nervous system (CNS), hallmarks of some neurodegenerative diseases like multiple sclerosis. However, relatively little is known regarding the behavioural deficits associated with CPZ-feeding and much of what is known is contradictory.
Sen, Monokesh (R19837), Almuslehi, Mohammed S. (S32978), Coorssen, Jens R., Mahns, David A. (R11697), Shortland, Peter J. (R17436)   +4 more
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Interferon-γ Protects against Cuprizone-Induced Demyelination

Molecular and Cellular Neuroscience, 2000
Evidence suggests that interferon-gamma (IFN-gamma), a proinflammatory cytokine secreted by activated T lymphocytes, contributes a deleterious effect to immune-mediated demyelinating disorders such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
X, Gao, T A, Gillig, P, Ye, A J, D'Ercole, G K, Matsushima, B, Popko   +5 more
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The cuprizone model: regional heterogeneity of pathology

APMIS, 2012
The cuprizone model is a model of de‐ and remyelination secondary to oligodendrocyte death, likely to be mediated by an inhibition of mitochondrial function. The aim of this study was to characterize histopathological changes associated with de/remyelination in grey and white matter at different disease stages in C57Bl/6 mice after per oral ...
Stig, Wergeland, Øivind, Torkildsen, Kjell-Morten, Myhr, Sverre Jarl, Mørk, Lars, Bø   +4 more
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Cuprizone [Bis(Cyclohexylidenehydrazide)] is Selectively Toxic for Mature Oligodendrocytes

Neurotoxicity Research, 2013
Cuprizone [bis(cyclohexylidenehydrazide)]-induced toxic demyelination is an experimental animal model commonly used to study de- and remyelination in the central nervous system. In this model, mice are fed with the copper chelator cuprizone which leads to oligodendrocyte death with subsequent demyelination.
Jelena Skuljec, Paraskevi N Koutsoudaki, Vikramjeet Singh   +2 more
exaly   +3 more sources

Probenecid-treatment reduces demyelination induced by cuprizone feeding

Journal of Chemical Neuroanatomy, 2017
Recent experiments showed that a pannexin-1 inhibitor, probenecid, reduced clinical symptoms in the murine experimental autoimmune encephalomyelitis when applied during the initial phase of neuronal inflammation. An inflammatory component is also present in a toxically induced inflammation and demyelination using cuprizone diet.
Nadine, Hainz, Philipp, Becker, Daniel, Rapp, Stefan, Wagenpfeil, Bodo, Wonnenberg, Christoph, Beisswenger, Thomas, Tschernig, Carola, Meier   +7 more
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Cuprizone‐induced demyelination in CNP::GFP transgenic mice

Journal of Comparative Neurology, 2010
AbstractCuprizone (bis‐cyclohexanone oxaldihydrazone) was previously shown to induce demyelination in white matter enriched brain structures. In the present study we used the cuprizone demyelination model in transgenic mice expressing the enhanced green fluorescent protein (GFP) under the 2′‐3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase) promoter ...
Lucas, Silvestroff, Sandra, Bartucci, Eduardo, Soto, Vittorio, Gallo, Juana, Pasquini, Paula, Franco   +5 more
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Variation in the Response of Mice to Cuprizone

Research in Veterinary Science, 1973
Summary Weanling mice from 2 populations were fed 1% cuprizone for 59 days. During the experiment an assessment was made of the body weight and clinical condition of these mice and equivalent controls. The weight gain and behaviour of the control mice were similar throughout.
S, Elsworth, J M, Howell
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Pathological changes in mice with long term cuprizone administration

Neurochemistry International, 2019
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In MS, a long disease duration is known to be a strong risk factor for converting the clinical course of the disease from relapse remitting MS to secondary progressing MS.
Taichi, Nomura, Yoshio, Bando, Hitomi, Nakazawa, Soshi, Kanemoto, Shigetaka, Yoshida   +4 more
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Cuprizone neurotoxicity in the rat: Morphologic observations

Journal of the Neurological Sciences, 1988
Weanling male Wistar rats fed a diet containing 0.5-2% cuprizone developed intramyelinic edema of the cerebellar white matter, hilum of the dentate nucleus and superior cerebellar peduncle. Oligodendrocytes in these regions showed hyperchromatic nuclei and abnormally dense cytoplasm, with an increase in the number of free ribosomes and enlargement of ...
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Pain Responses in C57BL/6 Cuprizone Fed Mice

2014
Pain responses in C57BL/6 cuprizone fed mice Introduction: Demyelination is a known cause of neuropathic pain in diseases such as multiple sclerosis (MS). Pathophysiology of central neuropathic pain in MS patients is considered to be a consequence of deterioration of myelin sheaths.
Fenrich, Matija, Milić, Jakov, Muremi, Hendrik, Zelen, Ada   +3 more
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