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Copaxone treatment in the cuprizone mouse model
, 2018 Garea-Rodriguez, Enrique +3 more
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The Cuprizone Model: Dos and Do Nots [PDF]
Cells, 2020 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options.
Jiangshan Zhan +2 more
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The cuprizone model for demyelination
Acta Neurologica Scandinavica, 2008Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination.
Lars Bø
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Cuprizone neurotoxicity, copper deficiency and neurodegeneration
NeuroToxicology, 2010Cuprizone is used to obtain demyelination in mice. Cuprizone-treated mice show symptoms similar to several neurodegenerative disorders such as severe status spongiosus. Although it has a simple chemical formula, its neurotoxic mechanism is still unknown. In this work, we examined both physico-chemical properties and biological effects of cuprizone. Our
Federico Benetti +2 more
exaly +5 more sources
CD44 expression in the cuprizone model
Brain Research, 2020Numerous studies report that changes in extracellular matrix components and receptors, such as CD44, contribute to immune cell recruitment and thus lesion formation in multiple sclerosis (MS). In the present study, we used the cuprizone model to elucidate the expression pattern of CD44 in a toxin-induced MS model.
Christin Reinbach +6 more
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Investigation of Cuprizone Inactivation by Temperature
Neurotoxicity Research, 2017Animal models, such as cuprizone (bis-cyclohexanone oxaldihydrazone) feeding, are helpful to study experimental demyelination and remyelination in the context of diseases like multiple sclerosis. Cuprizone is a copper chelator, which when supplemented to the normal food of C57BL/6J mice in a concentration of 0.2% leads to oligodendroglial loss ...
Sandra, Heckers +6 more
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Synthesis and structural characterization of copper–cuprizone complexes
Dalton Transactions, 2022The chemistry of copper with cuprizone has challenged chemists for over 70 years. We characterize the classical ‘blue’ product, containing Cu(iii) and hydrolyzed cuprizone, and a green multimeric Cu(ii) product, containing unhydrolyzed cuprizone.
M. Jake Pushie +4 more
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Unravelling the chemical nature of copper cuprizone
Dalton Transactions, 2007During the last 50 years, formation of the highly chromogenic copper cuprizone complex has been exploited for spectrophotometric determinations of copper although the precise chemical nature of the resulting species has never been ascertained; we eventually show here, in contrast to current opinion, that copper cuprizone is a copper(III)complex.
MESSORI, LUIGI +5 more
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Acta Neuropathologica, 2009
Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents the most common neurological disorder in young adults in the Western hemisphere. There are several well-characterized experimental animal models that allow studying potential mechanisms of MS pathology.
Kipp, Markus +4 more
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Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the central nervous system and represents the most common neurological disorder in young adults in the Western hemisphere. There are several well-characterized experimental animal models that allow studying potential mechanisms of MS pathology.
Kipp, Markus +4 more
openaire +1 more source
Ultrastructural changes of cuprizone encephalopathy in mice
Toxicology and Applied Pharmacology, 1971Abstract The ultrastructural features of the encephalopathy induced by chronic feeding of cuprizone in the white matter of the cerebellar medulla of mice were characterized. Mice were fed a diet of 0.5% cuprizone for 8 wk and, under anesthesia, were perfused with 6% buffered glutaraldehyde.
R D, Hemm, W W, Carlton, J R, Welser
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