Biochemical properties of liver megamitochondria induced by chloramphenicol or cuprizone
Experimental Cell Research, 1977Abstract Comparative studies were performed on megamitochondria from mouse liver induced by treating infantile mice with chloramphenicol or cuprizone (biscyclohexanone oxaldihydrazone). As compared with normal mouse liver mitochondria, the following decreases in enzyme activities and cytochrome contents of chloramphenicol-induced megamitochondria ...
T, Wagner, J, Rafael
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The treatment effects of HET0016 on demyelinating Mice induced by cuprizone
Proceedings of 2012 IEEE-EMBS International Conference on Biomedical and Health Informatics, 2012Cytochrome P450s (CYP) ω-hydroxylase and its metabolites 20 - hydroxyeicosatetraenoic acid (20-HETE) play an important role in the central nervous system disorders. The purpose of this study was to determine the effects of the 20-HETE inhibitor, HET0016, on myelin sheath after demylination in mice.
Huina Wang +6 more
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The neurotoxicant, cuprizone, retards the differentiation of oligodendrocytes in vitro
Journal of the Neurological Sciences, 1999The effects of oxalyldihydrazone (cuprizone) on weanling rodents provided an early protocol for toxic demyelination in vivo, in which degeneration of oligodendrocytes preceded disruption of the myelin sheath, and in which remyelination could take place.
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Pathological changes in mice with long term cuprizone administration
Neurochemistry International, 2019Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In MS, a long disease duration is known to be a strong risk factor for converting the clinical course of the disease from relapse remitting MS to secondary progressing MS.
Taichi, Nomura +4 more
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Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination
International Immunopharmacology, 2019Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by recurrent and progressive demyelination, neuroinflammation and oligodendrocyte loss. The cuprizone (CPZ) model is characterized by primary and reversible demyelination, accompanied by oligodendrocyte loss and neuroinflammation. In the current study,
Ruo-Xuan Sui +9 more
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Spongiform encephalopathy induced in rats and guinea pigs by cuprizone
Experimental and Molecular Pathology, 1969Abstract Cuprizone (biscyclohexanone oxaldihydrazone) was neurotoxic when fed to rats and guinea pigs and produced spongy degeneration of the white and gray matter of various parts of the brain. Signs of neurologic disturbances and hydrocephalus did not occur.
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Effects of cuprizone on mitochondria
2023Jennifer McDonough, Sarah Sternbach
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Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone
Journal of the Neurological Sciences, 1973Abstract The superior cerebellar peduncles of mice fed a diet containing 0.5% cuprizone since weaning were examined. It was found that this tract was demyelinating after 4 weeks on the diet, a process which was almost complete after 5 weeks. Demyelination followed degeneration of oligodendrocytes.
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Cuprizone [Bis(Cyclohexylidenehydrazide)] is Selectively Toxic for Mature Oligodendrocytes
Neurotoxicity Research, 2013Jelena Skuljec +2 more
exaly
Mitochondrial complex IV is lost in neurons in the cuprizone mouse model
Mitochondrion, 2020Maria N Almé, L A Bindoff
exaly