Results 91 to 100 of about 245,137 (370)

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo*

Journal of Biological Chemistry, 2005
Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption.
Fusheng Yang, Giselle P. Lim, A. Begum, O. Ubeda, M. Simmons, Surendra S. Ambegaokar, Pingpin Chen, R. Kayed, C. Glabe, S. Frautschy, G. Cole   +10 more
semanticscholar   +1 more source

The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Molecules, 2021
Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers ...
Priti Tagde, Pooja Tagde, F. Islam, Sandeep Tagde, Muddaser Shah, Z. Hussain, M. Rahman, A. Najda, Ibtesam S. Alanazi, M. Germoush, H. Mohamed, Mardi M Algandaby, M. Nasrullah, N. Kot, Mohamed M. Abdel-Daim   +14 more
semanticscholar   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Lethal Effect of Various Derivatives of Curcumin on Trichomonas vaginalis in vitro

Iranian South Medical Journal, 2018
Background: Trichomoniasis is a common urogenital disease in the world. The first line of treatment for Trichomoniasis is metronidazole. Drug resistance and side effects of metronidazole urge researchers to seek new medications.
MoradAli Fouladvand, Afshin Barazesh, Rahim Tahmasebi, Khosro Mohammadi, Soliman Khorami   +4 more
doaj  

PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]

, 2012
Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M, Frautschy, Sally A, Ma, Qiu-Lan, Yang, Fusheng   +3 more
core   +1 more source

Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways

Journal of Cellular and Molecular Medicine, 2020
Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by changes in myocardial structure and function, together with cardiomyocyte ...
Bincheng Ren, Yu-Fei Zhang, Shan-shan Liu, Xiao-jing Cheng, Xin Yang, X. Cui, Xinrui Zhao, Hui Zhao, Minfeng Hao, Mengdan Li, Yuanyuan Tie, Li Qu, Xueyi Li   +12 more
semanticscholar   +1 more source

Curcumin Resource Database [PDF]

Database, 2015
Curcumin is one of the most intensively studied diarylheptanoid, Curcuma longa being its principal producer. This apart, a class of promising curcumin analogs has been generated in laboratories, aptly named as Curcuminoids which are showing huge potential in the fields of medicine, food technology, etc.
Kumar, Anil, Chetia, Hasnahana, Sharma, Swagata, Kabiraj, Debajyoti, Talukdar, Narayan Chandra, Bora, Utpal   +5 more
openaire   +2 more sources

Hybrid Nanofibers for Multimodal Accelerated Wound Healing

Advanced Healthcare Materials, EarlyView.
Fabrication of wound healing scaffolds based on biocompatible nanofibers. Nanofibers offering high surface area, flexibility, and biocompatibility significantly improved the healing outcome in vivo. Histological, immunological, and anti‐inflammatory markers are noticeably better in treated wounds.
Viraj P. Nirwan, Bence Bajusz, Norbert Fabók, Marina Rudan Dimlic, Jelena Budimir, Tshepang Mqatywa, Miklós Gyöngy, Márton Ferencz, Dorottya Kocsis, Olexandr Bondarenko, Mariia Rolduhina, Milena Lengyel, Istvan Antal, Rebecca Hengsbach, Franciska Erdő, Amir Fahmi   +15 more
wiley   +1 more source

Curcumin affects HSP60 folding activity and levels in neuroblastoma cells [PDF]

, 2020
The fundamental challenge in fighting cancer is the development of protective agents able to interfere with the classical pathways of malignant transformation, such as extracellular matrix remodeling, epithelial\u2013mesenchymal transition and ...
Campanella C., Cappello F., CARUSO BAVISOTTO C., Lo Cascio F., Marino Gammazza A., Mocciaro E., Pace A., Palumbo Piccionello A., Vergilio G., Vitale A.M.   +9 more
core   +2 more sources