Nutrients, 2019 Curcumin, a polyphenol extracted from Curcuma longa in 1815, has gained attention from scientists worldwide for its biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral), among which its anticancer potential has been the ...
A. Giordano, G. Tommonaro
semanticscholar +6 more sources
Hydrophobic hydration driven self-assembly of Curcumin in water: Similarities to nucleation and growth under large metastability, and an analysis of water dynamics at heterogeneous surfaces [PDF]
, 2014 As the beneficial effects of curcumin have often been reported to be limited to its small concentrations, we have undertaken a study to find the aggregation properties of curcumin in water by varying the number of monomers. Our molecular dynamics simulation results show that the equilibrated structure is always an aggregated state with remarkable ...
Bagchi, Biman +2 more
arxiv +3 more sources
On the properties of a single OPLS-UA model curcumin molecule in water, methanol and dimethyl sulfoxide. Molecular dynamics computer simulation results [PDF]
Condens. Matter Phys., vol. 20, No. 2, 23003 (2017), 2017 The properties of model solutions consisting of a solute --- single curcumin molecule in water, methanol and dimethyl sulfoxide solvents have been studied using molecular dynamics (MD) computer simulations in the isobaric-isothermal ensemble. The united atom OPLS force field (OPLS-UA) model for curcumin molecule proposed by us recently [J. Mol.
Ilnytskyi, J. M. +2 more
arxiv +5 more sources
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo* [PDF]
Journal of Biological Chemistry, 2005 Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption.
Fusheng Yang +10 more
semanticscholar +2 more sources
Curcumin and Endometriosis [PDF]
International Journal of Molecular Sciences, 2020 Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis.
Alexandre Vallée, Yves Lecarpentier
openaire +2 more sources
Visible light is a better co-inducer of apoptosis for curcumin-treated human melanoma cells than UVA [PDF]
, 2013 Curcumin attracts worldwide scientific interest due to its anti-proliferative and apoptosis inducing effects on different tumor cells at concentrations ranging from 10 to 150 µM (3.7–55 µg/ml).
Bernd, August +7 more
core +11 more sources
Structural aspects of the clustering of curcumin molecules in water. Molecular dynamics computer simulation study [PDF]
Condensed Matter Physics, 2022, vol. 25, No. 2, 23201, 2022 We explore clustering of curcumin molecules in water by using the OPLS-UA model for the enol conformer of curcumin (J. Mol. Liq., 223, 707, 2016) and the SPC-E water model. With this purpose, solutions of 2, 4, 8, 12, 16 and 20 curcumin molecules in 3000 water molecules are studied by using extensive molecular dynamics computer simulations.
arxiv +1 more source
Molecules, 2016 Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides a brief review about the origin, bioavailability and new research on curcumin and synthetized derivatives.
Mario Pulido-Moran +3 more
openaire +6 more sources
Aspects of the microscopic structure of curcumin solutions with water-dimethylsulfoxide solvent. Molecular dynamics computer simulation study [PDF]
Condensed Matter Physics, 2023, vol. 26, No. 3, 33605, 2023 We explore some aspects of the microscopic structure of curcumin solutions with water-dimethylsulfoxide solvent of variable composition. Molecular dynamics computer simulations at isobaric-isothermal conditions are used for this purpose. The model consists of the OPLS-UA type model for the enol conformer of curcumin (J. Mol.
arxiv +1 more source
Curcumin: Biological Activities and Modern Pharmaceutical Forms
Antibiotics, 2022 Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action.
Maja Urošević +5 more
semanticscholar +1 more source