Results 51 to 60 of about 121,413 (201)

Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway

Biomedical Journal
Background: Curcumin ameliorates bone loss by inhibiting osteoclastogenesis. Curcumin inhibits RANKL-promoted autophagy in osteoclast precursors (OCPs), which mediates its anti-osteoclastogenic effect.
Dianshan Ke, Haoying Xu, Junyong Han, Hanhao Dai, Xinwen Wang, Jun Luo, Yunlong Yu, Jie Xu   +7 more
doaj   +1 more source

Textural Properties of Carbopol^® Gel with Curcumin and Curcumin–HPβCD Inclusion Complex and Biological Activities

Gels
The aim of this study was to prepare curcumin/2-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex, evaluate the antioxidant and antimicrobial activities of curcumin and curcumin in inclusion complex, as well as to examine the effect of curcumin and ...
Maja Urošević, Vesna Nikolić, Vesna Savić, Tatjana Mihajilov-Krstev, Ivana Gajić, Ana Dinić, Milica Martinović, Ljubiša Nikolić   +7 more
doaj   +1 more source

In vitro evaluation of antioxidant and neuroprotective effects of curcumin loaded in Pluronic micelles

Biotechnology & Biotechnological Equipment, 2016
Curcumin is a polyphenolic substance with attractive pharmacological activities (e.g. antioxidant, anti-inflammatory, anticancer). Incorporation of curcumin in polymeric micelles could overcome the problems associated with its instability and low aqueous
Cvetelina Gorinova, Denitsa Aluani, Yordan Yordanov, Magdalena Kondeva-Burdina, Virginia Tzankova, Cvetelina Popova, Krassimira Yoncheva   +6 more
doaj   +1 more source

Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Pharmaceutics, 2019
Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds.
Chawanphat Muangnoi, Pahweenvaj Ratnatilaka Na Bhuket, Ponsiree Jithavech, Wisut Wichitnithad, Onsiri Srikun, Chakkrapan Nerungsi, Suthiluk Patumraj, Pornchai Rojsitthisak   +7 more
doaj   +1 more source

Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System

Bioinorganic Chemistry and Applications, 2010
The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn2+,Cu2+,Mg2+,Se2+), in “green media” and evaluate its stability in vitro compared to curcumin alone.
Bachar Zebib, Zéphirin Mouloungui, Virginie Noirot   +2 more
doaj   +1 more source

The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes

Molecules, 2015
Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability.
Xing Chen, Li-Qiang Zou, Jing Niu, Wei Liu, Sheng-Feng Peng, Cheng-Mei Liu   +5 more
doaj   +1 more source

pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy

Journal of Advanced Research, 2019
Nanoparticle-mediated targeted delivery of bioactive natural compounds has recently been gaining much interest for breast cancer therapy. Herein, phenyl boronic acid (PBA)-conjugated and pH-responsive ZnO nanoparticles (diameter ∼40 nm) were synthesized ...
Mousumi Kundu, Pritam Sadhukhan, Noyel Ghosh, Sharmistha Chatterjee, Prasenjit Manna, Joydeep Das, Parames C. Sil   +6 more
doaj   +1 more source

Quantification of curcumin and molecular analysis of curcumin synthase genes in Curcuma alismatifolia genotypes

Folia Horticulturae
Curcumin content and expression patterns of curcumin synthase (CURS) genes in three tissues (corms, leaves and inflorescences) of 16 Curcuma alismatifolia genotypes were analysed in this study.
Tao Can, Huang Weiwei, Jiang Qi, Lu Luanmei, Ke Lingjun, Yu Huiwen   +5 more
doaj   +1 more source

Photoinactivation Effects of Curcumin, Nano-curcumin, and Erythrosine on Planktonic and Biofilm Cultures of Streptococcus mutans. [PDF]

Introduction: This in vitro study was conducted to assess the phototoxic effects of curcumin, nano-curcumin, and erythrosine on the viability of Streptococcus mutans (S. mutans) in suspension and biofilm forms. Methods: Various concentrations of curcumin
Nazifi, Morteza, Mazhari, Fatemeh, Menbari, Shaho, Ghazvini, Kiarash, Babaei, Kourosh, Banihashemrad, Ahmad, Ahrari, Farzaneh, Fekrazad, Reza   +7 more
core   +2 more sources

Comparative pharmacokinetic analysis of curcumin and curcumin O-glucuronide through curcumin nano-gel-based delivery system using liquid chromatogram tandem mass spectrometry

Pakistan Journal of Pharmaceutical Sciences
Background: Curcumin exhibits limited oral bioavailability owing to its poor solubility and rapid metabolism. Objectives: To develop a novel curcumin nano-gel (CNG) and evaluate its pharmacokinetics following oral and rectal administration.
Lue Hong, Ruohan Man, Xiaowan Chen, Ziming Yang, Dingjie Shen, Wei Chen   +5 more
doaj   +1 more source