Results 61 to 70 of about 5,469 (180)

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Microencapsulation Curcuminoids for Effective Delivery in Pharmaceutical Application

Pharmaceutics, 2019
Curcuminoids have been long proven to possess antioxidant, anti-inflammatory and antibacterial properties which are crucial in their role as a pharmacological active agent.
Lee Fung Ang, Yusrida Darwis, Lip Yee Por, Mun Fei Yam   +3 more
doaj   +1 more source

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Photodynamic Action of Synthetic Curcuminoids against Staphylococcus aureus: Experimental and Computational Evaluation

Chemistry
Natural curcumin is composed of three curcuminoids, namely curcumin (CUR), deme-thoxycurcumin (DMC) and bis-demethoxycurcumin (BDMC). These compounds are utilized in various biophotonics applications, including photodynamic therapy (PDT). This work aimed
Nícolas J. Melo, Jennifer M. Soares, Lívia N. Dovigo, Christian Carmona-Vargas, Antônio S. N. Aguiar, Adriana C. dos Passos, Kleber T. de Oliveira, Vanderlei S. Bagnato, Lucas D. Dias, Natalia Inada   +9 more
doaj   +1 more source

Polyphenolic Components and Phytochemicals Deployed as Nutraceuticals and Pharmafoods

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This review (2010–2025) highlights the therapeutic potential of dietary polyphenols against cancer, diabetes, cardiovascular, neurological, and inflammatory diseases. It summarizes molecular mechanisms, clinical evidence, nanoparticle‐based delivery, bioavailability, safety, toxicity, and future prospects supporting polyphenols as promising therapeutic
Subhash Chandra, Md. Sakib Al Hasan, Md. A. K. Azad, Atasi Goswami   +3 more
wiley   +1 more source

Curcumin Attenuates Aroclor 1254‐Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
In HepG2 cells, Aroclor 1254 induced oxidative stress, DNA damage, apoptosis, and mutagenicity; co‐treatment with curcumin restored antioxidant defenses (GSH/thiols; SOD, CAT, GPx, GR, TrxR), reduced ROS and comet/8‐OHdG readouts, and attenuated caspase activation, demonstrating curcumin's hepatoprotective and genoprotective modulation of PCB toxicity.
Pınar Erkekoğlu, Selinay Başak Erdemli Köse, Hülya Tezel Yalçın, Deniz Arca Çakır   +3 more
wiley   +1 more source

Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice

NFS Journal, 2015
Background: Curcuminoids (curcumin, demethoxycurcumin, bis-demethoxycurcumin) are lipophilic polyphenols thought to be effective in the prevention and treatment of neurodegenerative disorders, of which mitochondrial dysfunction is a prominent feature. In
Alexa Kocher, Stephanie Hagl, Christina Schiborr, Gunter P. Eckert, Jan Frank   +4 more
doaj   +1 more source

Recent Advances in the Use of Natural Deep Eutectic Solvents for Natural Product Sample Preparation: Focus on Purification, Characterization, and Sustainability

Journal of Separation Science, Volume 49, Issue 7, July 2026.
ABSTRACT This review examines recent advances in the use of natural deep eutectic solvents (NaDES) for natural product sample preparation, with emphasis on extraction, purification, analytical compatibility, and sustainability. NaDES emerge as versatile, tunable, and biocompatible media that enhance the recovery and stability of diverse phytochemicals ...
Valeria Cedeño‐Fierro, Juan Felipe Grisales‐Mejía, Harlen Gerardo Torres Castañeda, Jose A. Mendiola   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparative Effects of Turmeric Secondary Metabolites Across Resorptive Bone Diseases

Metabolites
Background: Turmeric (Curcuma longa L.) rhizomes, whose secondary metabolites include polyphenols and terpenoids, have been used medicinally for millennia.
Laura E. Wright, Jennifer B. Frye, Andrew G. Kunihiro, Barbara N. Timmermann, Janet L. Funk   +4 more
doaj   +1 more source