Results 61 to 70 of about 5,036,649 (295)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Bias Analysis in Entropy Estimation
, 2004 We consider the problem of finite sample corrections for entropy estimation. New estimates of the Shannon entropy are proposed and their systematic error (the bias) is computed analytically.
Abramowitz M +6 more
core +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2018 Nanopore sequencing technology has the potential to render other sequencing technologies obsolete with its ability to generate long reads and provide portability.
Alkan, Can +4 more
core +2 more sources
IET Circuits, Devices & Systems, 2008 Advantages of using a current transformer (CT) for current sensing in switched mode power converters are that galvanic isolation is inherent, losses are low, the bandwidth is high and a high-amplitude output signal may be obtained. However, 'droop' occurs as a result of the magnetising current drawn.
McNeill, JN, Gupta, NK
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Reporting Error in Aircraft Maintenance: are engineers reporting safety concerns? : A thesis presented in partial fulfilment of the requirements for the degree of Master of Aviation At Massey University, Manawatu, New Zealand [PDF]
, 2015 Aviation accidents seldom occur as the consequence of an isolated incident, but as the result of a series of contributing factors. The industry has focussed on detecting and predicting these casual factors to support accident prevention.
Twyman, Kirsty
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
High-accuracy current measurement with low-cost shunts by means of dynamic error correction [PDF]
Journal of Sensors and Sensor Systems, 2016 Measurement of electrical current is often performed by using shunt resistors. Thermal effects due to self-heating and ambient temperature variation limit the achievable accuracy, especially if low-cost shunt resistors with increased temperature ...
P. Weßkamp, J. Melbert
doaj +1 more source