Results 41 to 50 of about 135,230 (216)
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2010 本研究透過系統化教學設計之方式，融合教科書之主要語法結構，發展出適合國中七年級學生的英語寫作教學課程。 本研究得到之研究結論如下： 一、Dick 和 Carey 的系統化教學設計理念，能協助教學者設立明確的教學目標。 二、研究對象填寫之「英語造句書寫興趣量表」前後測，以成對樣本t 檢定分析， 顯示以系統化教學設計英語造句寫作課程，能提升學習者的英語造句書寫興趣。 三、量表中四個分量表－「個人寫作知覺」、「寫作技巧」、「寫作喜好」和「英語學 習態度」之前後測，進行成對樣本t 檢定 ...
林婕婷 Lin, Chieh-Ting +2 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
South African Journal of Education, 2017 The concept of student teaching practice is globally rooted in training pre-service teachers to work within diverse schools and learner populations, in dissimilar contexts.
Thabisile Nkambule +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
度量化的身體：學校體適能檢測的權力技術 The Quantified Body: The Technique of Power of Physical Fitness Tests at School
臺灣教育社會學研究, 2014 本論文藉由跨領域的形式提供另一種體適能的研究觀點。從分析學校體適能的檢測機制，探討其對學生身體規訓與抵抗的可能。基於這樣的理念與架構，研究者先以自己任教健體領域的六年級學生為對象，透過兒童哲學形式的討論，並考量性別均衡與體適能常模的常態分布後，選出10位六年級學生作為主要訪談對象。此外，為了瞭解體適能檢測的權力關係如何運作，研究者除了參加體適能檢測員的培訓外，也選擇兩所熟識的國小進行觀察。本研究發現如下：一、體適能檢測透過柔軟度的訓練、身體被看見的安排、體適能護照的登錄、常模的規範化裁決 ...
陳鴻文Hung-Wen Chen
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Education SciencesUndergraduate engineering programs are associated with high stress and heavy workloads that impact the wellness of students. One university offers a unique undergraduate engineering education program structure offering two degree plan lengths, four or ...
Stephanie Shaw, Jeni Spencer
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FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source