The preparative synthetic approach to α,α-difluoro-γ-aminobutyric acid
Журнал органічної та фармацевтичної хімії, 2020 Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion.
Maksym Ya. Bugera +3 more
doaj +1 more source
Efficient Synthesis of O-Succinimidyl-(tert-Butoxycarbonylamino)methyl Carbamates Derived from α-Amino Acids Accelerated by Ultrasound: Application to the Synthesis of Ureidodipeptides [PDF]
, 2008 The synthesis of O-succinimidyl-(tert-butoxycarbonylamino)methyl carbamates employing isocyanates made through the Curtius rearrangement of Boc-amino acid azides in the presence of N-hydroxysuccinimide under the influence of ultrasound is ...
Kantharaju, . +2 more
core +1 more source
Ureido Derivatives of Neoabietic Acid
Molbank, 2018 A series of ureido derivatives of neoabietic acid were synthesized by application of Curtius rearrangement reaction to neoabietic acid and amines. Structure characterization of these compounds was done by 1H-NMR, 13C-NMR and HRMS spectral analysis.
Xinyu Gao +4 more
doaj +1 more source
A Facile Synthesis of C-terminal Neoglycopeptides: Incorporation of Urea Moiety between Sugars and Peptides Employing Curtius Rearrangement [PDF]
, 2008 Incorporation of urea moiety in the synthesis of C-terminal neoglycopeptides has been demonstrated through the reaction between suitably protected glycosylamine and Fmoc-peptidyl isocyanates or carbamates.
Hemantha, H.P. +2 more
core +1 more source
Reactive & Efficient: Organic Azides as Cross-Linkers in Material Sciences
Molecules, 2020 The exceptional reactivity of the azide group makes organic azides a highly versatile family of compounds in chemistry and the material sciences. One of the most prominent reactions employing organic azides is the regioselective copper(I)-catalyzed ...
Marvin Schock, Stefan Bräse
doaj +1 more source
A short synthesis of (±)-cherylline dimethyl ether
Beilstein Journal of Organic Chemistry, 2009 A synthesis of (±)-cherylline dimethyl ether is reported. The key steps involved are Michael-type addition, radical azidonation of an aldehyde, Curtius rearrangement, and reduction of an isocyanate intermediate followed by Pictet–Spengler cyclization.
Bhima Y. Kale +7 more
doaj +1 more source
Mechanochemical reactions studied by in situ Raman spectroscopy : base catalysis in liquid-assisted grinding [PDF]
, 2015 In situ Raman spectroscopy was employed to study the course of a mechanochemical nucleophilic substitution on a carbonyl group.
Biliškov, Nikola +8 more
core +1 more source
Triazolinediones as highly enabling synthetic tools [PDF]
, 2016 Triazolinediones (TADs) are unique reagents in organic synthesis that have also found wide applications in different research disciplines, in spite of their somewhat "exotic" reputation.
Billiet, Stijn +5 more
core +1 more source
Convenient Synthesis and Antimicrobial Activity of Some Novel Amino Acid Coupled Triazoles
Molecules, 2010 This study describes a promising one-pot synthesis of [2-(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetyl]-amino acid methyl esters 6a-h and dipeptides 10a-e, which were successfully synthesized starting from amino acid esters 5a-h, 9a-e and azides 4,
S. M. El Rayes
doaj +1 more source
Synthesis of N-Z, N′-Formyl α-Amino Acid Derived Gem-Diamines [PDF]
, 2008 A variety of N-carbobenzoxy, N′-formyl gem-diaminoalkyl derivatives have been obtained through Goldsmith-Wick reaction of Z-α-amino acid/peptide acid derived isocyanates with 96% HCOOH in presence of 4-dimethylaminopyridine (DMAP) as catalyst.
Narendra, N., Sureshbabu, V.V.
core +2 more sources