Results 41 to 50 of about 265,896 (190)

An Efficient Synthesis of PARP Inhibitors Containing a 4-Trifluoromethyl Substituted 3,6,7,7a-Tetrahydro- 1H-pyrrolo[3,4-d]pyrimidine-2,5-dione Scaffold

Журнал органічної та фармацевтичної хімії, 2023
Poly(ADP-ribose) polymerases (PARPs) are key enzymes in the DNA repair pathway. Inhibitors of these enzymes belong to a new type of anticancer drugs that selectively kill cancer cells by targeting the homologous recombination genetic defects.
Oleh O. Lukianov, Viktor M. Tkachuk, Diana S. Stepanova, Isabelle Gillaizeau, Volodymyr A. Sukach   +4 more
doaj   +1 more source

The Synthesis and Acid-base Properties of α-(Fluoromethyl)- and α-(Difluoromethyl)-substituted Cyclobutane Building Blocks

Журнал органічної та фармацевтичної хімії, 2023
Aim. To synthesize cyclobutane-derived amines and carboxylic acids bearing CH2F or CHF2 groups in the α position; to determine the regularities of the effect of fluoroalkyl substituents on the acid-base properties of the title compounds.
Oleksandr Demchuk, Oleksandr Grygorenko
doaj   +1 more source

Reaction of N-Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo. [PDF]

ChemMedChem
Nitric oxide induces decomposition of electron‐deficient aminoferrocene drugs 4 with formation of oxime 7, which is derived from the upper cyclopentadienyl ligand. Drugs 4 are not responsive to hydrogen peroxide. Based on the latter reaction, the fluorogenic probes are developed for detecting NO in cells and inflammation in vivo.
Selin R, Özkan HG, Bila G, Bilyy R, Mokhir A.   +4 more
europepmc   +2 more sources

Convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines

Журнал органічної та фармацевтичної хімії, 2021
Aim. To develop convenient approaches to the synthesis of 6-amino- and 6-oxoimidazo[4,5-b]pyrazolo[3,4-e]pyridines as promising biologically active scaffolds. Results and discussion.
Georgiy G. Yakovenko, Mikhailo V. Vovk
doaj   +1 more source

The preparative synthetic approach to α,α-difluoro-γ-aminobutyric acid

Журнал органічної та фармацевтичної хімії, 2020
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion.
Maksym Ya. Bugera, Andrii V. Herbeda, Karen V. Tarasenko, Ivan S. Kondratov   +3 more
doaj   +1 more source

Ureido Derivatives of Neoabietic Acid

Molbank, 2018
A series of ureido derivatives of neoabietic acid were synthesized by application of Curtius rearrangement reaction to neoabietic acid and amines. Structure characterization of these compounds was done by 1H-NMR, 13C-NMR and HRMS spectral analysis.
Xinyu Gao, Niping Feng, Yuhan Zi, Jianguo Cao, Guozheng Huang   +4 more
doaj   +1 more source

Reactive & Efficient: Organic Azides as Cross-Linkers in Material Sciences

Molecules, 2020
The exceptional reactivity of the azide group makes organic azides a highly versatile family of compounds in chemistry and the material sciences. One of the most prominent reactions employing organic azides is the regioselective copper(I)-catalyzed ...
Marvin Schock, Stefan Bräse
doaj   +1 more source

A short synthesis of (±)-cherylline dimethyl ether

Beilstein Journal of Organic Chemistry, 2009
A synthesis of (±)-cherylline dimethyl ether is reported. The key steps involved are Michael-type addition, radical azidonation of an aldehyde, Curtius rearrangement, and reduction of an isocyanate intermediate followed by Pictet–Spengler cyclization.
Bhima Y. Kale, Ananta D. Shinde, Swapnil S. Sonar, Bapurao B. Shingate, Sanjeev Kumar, Samir Ghosh, Soodamani Venugopal, Murlidhar S. Shingare   +7 more
doaj   +1 more source

Convenient Synthesis and Antimicrobial Activity of Some Novel Amino Acid Coupled Triazoles

Molecules, 2010
This study describes a promising one-pot synthesis of [2-(5-benzyl-4-phenyl-4H-[1,2,4]triazol-3-thio)-acetyl]-amino acid methyl esters 6a-h and dipeptides 10a-e, which were successfully synthesized starting from amino acid esters 5a-h, 9a-e and azides 4,
S. M. El Rayes
doaj   +1 more source

Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2‐Bis(Diazo)Alkanes to 1,2,3,4‐Tetrazines and Subsequent Fragmentations

Angewandte Chemie, EarlyView.
DFT calculations of the 8π‐electrocyclization of 1,2‐bis(diazo)alkanes and of other bis‐1,3‐dipoles reveal that this process can establish a so far ignored route to heterocycles such as 1,2,3,4‐tetrazines. Alternative reaction channels via carbenes or nitrenes leading to fragmentation products are discussed.
Hans‐Ulrich Reissig, Ernst‐Ulrich Würthwein   +1 more
wiley   +2 more sources