Results 41 to 50 of about 591,277 (274)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of Manufacturing and Materials ProcessingOptical surface deviations in ophthalmic optics arise from fast tool servo errors, the tool footprint, freeform surface residuals, and the freeform surface curvature responses across processing stages.
Xin Chen, Kai Cheng, Yuanzheng Fu
doaj +1 more source
Design of a novel bandgap reference
Dianzi Jishu Yingyong, 2018 Based on the traditional first-order compensation bandgap reference analysis, this paper proposes a novel high-order compensation technique and uses this technique to design a curvature compensation voltage reference with a low temperature coefficient ...
Du Tao +4 more
doaj +1 more source
Discrete-Time Takagi-Sugeno Stabilization Approach Applied in Autonomous Vehicles
Journal of Sensor and Actuator Networks, 2022 This paper deals with a new robust control design for autonomous vehicles. The goal is to perform lane-keeping under various constraints, mainly unknown curvature and lateral wind force.
Mohamed Ali Jemmali, Hussein T. Mouftah
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Compensation Review Board (CRB) opinions. 2005
, 2005 Updated annually; Began in 2003?; Title from home page last rev. Feb. 6, 2007 (publisher's web site, viewed Mar.
Connecticut. Workers' Compensation Commission. Compensation Review Board.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Compensation Review Board (CRB) opinions. 2006
, 2006 Updated annually; Began in 2003?; Title from home page last rev. Feb. 6, 2007 (publisher's web site, viewed Mar.
Connecticut. Workers' Compensation Commission. Compensation Review Board.
core +1 more source
Remote SensingAccurate estimation of the Doppler centroid is a prerequisite for achieving high-quality Synthetic Aperture Radar imaging. In highly squinted working scenarios, traditional frequency-domain methods depend on antenna pattern fitting.
Ya Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source