Results 51 to 60 of about 591,277 (274)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
A bandgap reference source with higher-order curvature compensation
Dianzi Jishu YingyongBased on the 0.18 μm BCD process, a higher-order curvature compensation bandgap reference with low temperature coefficient is proposed. On the basis of the basic Kuijk bandgap reference structure, the VBE linearization method is used to perform high ...
Huang Chaoxuan, Li Xiankun, Wei Jinghe
doaj +1 more source
The Effect of Subtalar Motion on Calcaneal Osteotomies
Foot & Ankle Orthopaedics, 2019 Category: Ankle Arthritis, Hindfoot Introduction/Purpose: Background There is evidence that the subtalar joint may compensate for supramalleolar deformities and thereby slower or halt progression of ankle arthritis.
Fabian Krause MD +3 more
doaj +1 more source
Fast Aberrations Compensation in Digital Holographic Microscopy Based on Phase Transformation
IEEE Photonics Journal, 2020 A fast aberrations compensation method for digital holographic microscopy based on phase transformation is proposed. Phase transformation for original unwrapped phase can be done using rotation transformation with 180° and reflection ...
Dingnan Deng, Weijuan Qu
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Integrated Error Compensation for Robotic Arm Polishing of Cylindrical Aspheric Optical Components
MachinesThis research tackles the intricate machining properties of cylindrical aspheric surfaces with a versatile adaption approach utilizing a robotic arm and a compact tool head, incorporating trajectory optimization.
Yao Liu +4 more
doaj +1 more source