Results 61 to 70 of about 1,546 (196)

Histidine–tryptophan–ketoglutarate solution versus multidose cardioplegia for myocardial protection in cardiac surgeries: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery, 2022
Background Surgical procedures in the heart requires protection of the heart from ischemia–reperfusion injury. Cardioplegia is the primary myocardial protective method in use.
Muayad Albadrani
doaj   +1 more source

Lack of Melatonin Secretion Induced by Moderate Hypothermia During Aortic‐Arch Surgery: Possible Implications in Neurological Outcomes

Journal of Cardiac Surgery, Volume 2026, Issue 1, 2026.
Preclinical data from the peculiar animal model of “synthetic torpor” (ST), a reversible hypothermic condition resembling natural torpor but pharmacologically induced in rats (a nonhibernating mammal), suggest that in hypothermic conditions, the neuroprotective effects of melatonin are strongly enhanced.
Alessandro Leone, Alessandra Occhinegro, Emiliana Piscitiello, Paola Paterini, Simone Bugani, Carlo Mariani, Chiara Nocera, Timna Hitrec, Roberto Amici, Davide Pacini, Marco Luppi, Satabdi Datta Choudhury   +11 more
wiley   +1 more source

Intraoperative Biochemical Variations and Short‐Term Cognitive Outcomes After Histidine–Tryptophan–Ketoglutarate Versus Plegisol Cardioplegia in Adult Cardiac Surgery

Journal of Cardiac Surgery, Volume 2026, Issue 1, 2026.
Background Cardioplegia is essential for myocardial protection during cardiac surgery with cardiopulmonary bypass (CPB). Histidine–tryptophan–ketoglutarate (HTK) solution, an intracellular‐type cardioplegia, offers prolonged myocardial protection with single‐dose administration, whereas Plegisol, an extracellular‐type crystalloid cardioplegia solution ...
Yu-Ning Hu, Yu-Ming Chang, Meng-Ta Tsai, Hui-Ling Chan, Dean Chou, Yu-Ching Huang, Chou-Ching Lin, Jun-Neng Roan, Irsa Hasan   +8 more
wiley   +1 more source

The efficacy of custodiol as blood cardioplegia for myocardial protection in adult cardiac surgery [PDF]

Journal of Cardiothoracic Surgery, 2015
Custodiol cardioplegia is attractive method of myocardial protection, as a single dose provides a long period of preservation. Despite widespread use in Europe, the available data confirming its efficacy is little compared with conventional methods of cardioplegia.
Moursi, Ihab Mohamed Yehya, Halawa, Shaban   +1 more
openaire   +1 more source

Lidocaine and Pinacidil Added to Blood versus Crystalloid Cardioplegic Solutions: Study in Isolated Hearts

Brazilian Journal of Cardiovascular Surgery
Objective: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents ...
Helison Pereira do Carmo, Karla Reichert, Daniela Diógenes de Carvalho, Lindemberg da Mota Silveira-Filho, Karlos Vilarinho, Pedro Oliveira, Orlando Petrucci   +6 more
doaj   +1 more source

Experimental Static Cold Storage of the Rat Uterus: Protective Effects of Relaxin- or Erythropoietin-Supplemented HTK-N Solutions

Biomedicines, 2022
Uterus transplantation (UTx) is the only treatment method for women with absolute uterine infertility. Currently, the number of grafts retrieved from deceased donors is increasing; hence, prolonged cold ischemia time is inevitable.
Lina Jakubauskiene, Matas Jakubauskas, Gintare Razanskiene, Bettina Leber, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer   +7 more
doaj   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu, Sheng Hu, Alexander Tamalunas, Oluwafemi Kale, Yajie Xu, Christian G. Stief, Martin Hennenberg   +6 more
wiley   +1 more source

Evaluation of Perfluorohexyloctane/Polydimethylsiloxane for Pancreas Preservation for Clinical Islet Isolation and Transplantation

Cell Transplantation, 2016
This study aimed to evaluate a 50:50 mix of perfluorohexyloctane/polydimethylsiloxane 5 (F6H8S5) preservation of pancreases in a clinical setting compared with standard solutions for 1) cold ischemia time (CIT) 20 h.
Magnus Ståhle, Aksel Foss, Bengt Gustafsson, Marko Lempinen, Torbjörn Lundgren, Ehab Rafael, Gunnar Tufveson, Bastian Theisinger, Daniel Brandhorst, Olle Korsgren, Andrew Friberg   +10 more
doaj   +1 more source

Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C [PDF]

The Annals of Thoracic Surgery, 2002
The aim of this experimental study was to compare the protective efficacy of the cardioplegic solutions Celsior and Custodiol. Canine hearts were examined with regard to energy metabolism and early postischemic recovery after 8 or 12 hours of ischemia at 5 degrees C.Canine hearts were preserved with Celsior or Custodiol (each n = 19).
Juergen, Ackemann, Wolfgang, Gross, Martin, Mory, Michael, Schaefer, Martha-Maria, Gebhard   +4 more
openaire   +2 more sources

Protective effects of neutrophil serine protease inhibition against ischemia–reperfusion injury in lung or heart transplantation

The FEBS Journal, Volume 292, Issue 22, Page 5877-5887, November 2025.
A major complication of organ transplantation is primary graft dysfunction, which represents the leading cause of early post‐transplantation morbidity and mortality. Pre‐operative depletion of neutrophil serine proteases in circulating neutrophils by pretreatment with a cathepsin C inhibitor in recipients could prevent early post‐operative ...
Sevil Korkmaz‐Icöz, Gábor Szabó, Artur Gieldon, Patrick P. McDonald, Alexey Dashkevich, Ali Önder Yildirim, Brice Korkmaz   +6 more
wiley   +1 more source