Results 201 to 210 of about 152,387 (341)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Neural network approach enhancing churn prediction with categorical encoding and standard scaling. [PDF]

open access: yesSci Rep
Bhattacharjee B   +7 more
europepmc   +1 more source

Six artificial intelligence innovation strategies applied to autism spectrum disorder research: A narrative review

open access: yesPediatric Investigation, EarlyView.
Six artificial intelligence strategies advance autism research from tool optimization to paradigm shift: causal modeling, spatiotemporal networks, multimodal integration, digital twins, social cognition mapping, collaborative learning, and context‐aware interventions for precision care.
Ting Zhang   +3 more
wiley   +1 more source

Leveraging Customer Lifetime Value (CLV) for Strategic Marketing and Financial Performance Optimization [PDF]

open access: bronze
Henrique Turin Moreira   +3 more
openalex   +1 more source

Effect of recycling on mechanical and physical properties of polycarbonate/acrylonitrile–butadiene–styrene/poly(methyl methacrylate) (PC/ABS/PMMA) blends

open access: yesPolymer International, EarlyView.
The 100% recycling of optimal polycarbonate/acrylonitrile–butadiene–styrene/poly(methyl methacrylate) (PC/ABS/PMMA) blends, identified through the mixture design, over multiple successive cycles provides valuable insights into their life cycle. Subsequently, chemical, rheological, thermal and mechanical characterizations will be carried out to evaluate
Rahma Ezzeddine   +3 more
wiley   +1 more source

Digitizing collections to unlock the full potential of palynology: A case study with the Smithsonian palynology collection

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Large palynological collections have been built over decades and contain vital information. However, they are often difficult to access and use effectively. What is the point of having such collections if they are not fully utilizable? To solve this problem, we digitized the Smithsonian palynological collection using both light and confocal microscopy.
Carlos Jaramillo   +37 more
wiley   +1 more source

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