Results 111 to 120 of about 971,429 (302)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Seasonality Effects on Consumers Preferences Over Quality Attributes of Different Beef Products

open access: yes, 2019
Using discrete choice modelling, the study investigates 946 American consumers willingness-to-pay and preferences for diverse beef products. A novel experiment was used to elicit the number of beef products that each consumer would purchase. The range of
Ardeshiri, Ali   +2 more
core   +1 more source

Grading Method of Fresh Cut Rose Flowers Based on Improved YOLOv8s

open access: yes智慧农业
ObjectiveThe fresh cut rose industry has shown a positive growth trend in recent years, demonstrating sustained development. Considering the current fresh cut roses grading process relies on simple manual grading, which results in low efficiency and ...
ZHANG Yuyu   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Economic Impacts of Spending Cuts and Tax Increases [PDF]

open access: yes, 2004
Part of a series that examines California's budget and its relationship to the state's economy. Addresses the call on the Legislature, by the Legislative Analyst's Office, for a discussion of tax increase as part of California's long-term budget ...

core  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

The Gramm-Rudman-Hollings act: More revisions? [PDF]

open access: yes
During the first half of the eighties, the U.S. federal deficit rose from $ 74 bn to $ 212 bn. When the Congressional Budget Office (CBO) projected in August 1985 that the deficit would further increase to $ 285 bn by 1990, the Gramm-Rudman-Hollings Act (
Kauffmann, Barbara
core  

The Fall and Rise of Household Saving [PDF]

open access: yes, 2009
[Excerpt] Household saving matters for two reasons. First, it is an important source of funds to finance domestic investment. Second, it is the means by which workers accumulate wealth and maintain their living standard into retirement.
Cashell, Brian W
core   +2 more sources

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