Results 71 to 80 of about 134,257 (306)

Immune Microenvironment Related Competitive Endogenous RNA Network as Powerful Predictors for Melanoma Prognosis Based on WGCNA Analysis

Frontiers in Oncology, 2020
Cutaneous melanoma is the most life-threatening skin malignant tumor due to its increasing metastasis and mortality rate. The abnormal competitive endogenous RNA network promotes the development of tumors and becomes biomarkers for the prognosis of ...
Yaqi Cheng, Chengxiu Liu, Yurun Liu, Yaru Su, Shoubi Wang, Lin Jin, Qi Wan, Ying Liu, Chaoyang Li, Xuan Sang, Liu Yang, Chang Liu, Xiaoran Wang, Zhichong Wang   +13 more
doaj   +1 more source

Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with skin cutaneous melanoma

Frontiers in Genetics, 2023
Skin cutaneous melanoma (SKCM) is the skin cancer that causes the highest number of deaths worldwide. There is growing evidence that the tumour immune microenvironment is associated with cancer prognosis, however, there is little research on the role of ...
Xin Shen, Lifeng Shang, Junwei Han, Yi Zhang, Wenkai Niu, Haiwang Liu, Hai Shi   +6 more
doaj   +1 more source

Histology of non-melanoma skin cancers. An Update [PDF]

, 2017
Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses ...
Cantisani, Carmen, Didona, Dario, Donati, Michele, Mercuri, Santo Raffaele, Paolino, Giovanni   +4 more
core   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma

Discover Oncology
Background Cutaneous malignant melanoma is a very aggressive and metastatic form of skin cancer, typically linked with poor outcomes. Advances in genomic analysis have underscored the crucial role of T cells in tumor immunity.
Wen-fei Luo, Ding-ming Song, Tong Shen, Yi-bo He, Hong-yang Du, Ming-jue Si, Lu-Wei Fang   +6 more
doaj   +1 more source

RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma

Biomolecules, 2021
Metastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogenesis
Paula Colón-Bolea, Rocío García-Gómez, Berta Casar   +2 more
doaj   +1 more source

Plasma microRNA levels following resection of metastatic melanoma [PDF]

, 2017
Melanoma remains the leading cause of skin cancer–related deaths. Surgical resection and adjuvant therapies can result in disease-free intervals for stage III and stage IV disease; however, recurrence is common.
Abrams, Zachary B, Agnese, Doreen, Carson III, William E, Fadda, Paolo, Howard, J. Harrison, Jacob, Naduparambil, Latchana, Nicholas, Markowitz, Joseph, Payne, Philip, Regan, Kelly, Terando, Alicia   +10 more
core   +3 more sources

Cutaneous Malignant Melanoma [PDF]

Mayo Clinic Proceedings, 2006
Skin cancer has become the most common neoplasm in the United States. With early diagnosis and appropriate management, most skin cancers have an overall 5-year survival rate of 95%. Cutaneous malignant melanoma (CMM), however, has a significantly higher morbidity and mortality, resulting in 65% of all skin cancer deaths. Although the long-term survival
Deborah L, Cummins, Jordan M, Cummins, Hardin, Pantle, Michael A, Silverman, Aimee L, Leonard, Arjun, Chanmugam   +5 more
openaire   +2 more sources

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Expressions of HLA Class II Genes in Cutaneous Melanoma Were Associated with Clinical Outcome: Bioinformatics Approaches and Systematic Analysis of Public Microarray and RNA-Seq Datasets

Diagnostics, 2019
Major histocompatibility complex (MHC) class II molecules, encoded by human leukocyte antigen (HLA) class II genes, play important roles in antigen presentation and initiation of immune responses.
Yang-Yi Chen, Wei-An Chang, En-Shyh Lin, Yi-Jen Chen, Po-Lin Kuo   +4 more
doaj   +1 more source