Results 61 to 70 of about 98,994 (359)

Immune Microenvironment Related Competitive Endogenous RNA Network as Powerful Predictors for Melanoma Prognosis Based on WGCNA Analysis

Frontiers in Oncology, 2020
Cutaneous melanoma is the most life-threatening skin malignant tumor due to its increasing metastasis and mortality rate. The abnormal competitive endogenous RNA network promotes the development of tumors and becomes biomarkers for the prognosis of ...
Yaqi Cheng, Chengxiu Liu, Yurun Liu, Yaru Su, Shoubi Wang, Lin Jin, Qi Wan, Ying Liu, Chaoyang Li, Xuan Sang, Liu Yang, Chang Liu, Xiaoran Wang, Zhichong Wang   +13 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma

Discover Oncology
Background Cutaneous malignant melanoma is a very aggressive and metastatic form of skin cancer, typically linked with poor outcomes. Advances in genomic analysis have underscored the crucial role of T cells in tumor immunity.
Wen-fei Luo, Ding-ming Song, Tong Shen, Yi-bo He, Hong-yang Du, Ming-jue Si, Lu-Wei Fang   +6 more
doaj   +1 more source

Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with skin cutaneous melanoma

Frontiers in Genetics, 2023
Skin cutaneous melanoma (SKCM) is the skin cancer that causes the highest number of deaths worldwide. There is growing evidence that the tumour immune microenvironment is associated with cancer prognosis, however, there is little research on the role of ...
Xin Shen, Lifeng Shang, Junwei Han, Yi Zhang, Wenkai Niu, Haiwang Liu, Hai Shi   +6 more
doaj   +1 more source

Cutaneous Malignant Melanoma [PDF]

Mayo Clinic Proceedings, 2006
Skin cancer has become the most common neoplasm in the United States. With early diagnosis and appropriate management, most skin cancers have an overall 5-year survival rate of 95%. Cutaneous malignant melanoma (CMM), however, has a significantly higher morbidity and mortality, resulting in 65% of all skin cancer deaths. Although the long-term survival
Deborah L, Cummins, Jordan M, Cummins, Hardin, Pantle, Michael A, Silverman, Aimee L, Leonard, Arjun, Chanmugam   +5 more
openaire   +2 more sources

Prospects for non-immunological molecular therapeutics in melanoma [PDF]

, 2010
In 2006 there were 60,000 new cases of cutaneous melanoma in the European Union and 13,000 deaths (www.europeancancerleagues.org). Currently available systemic treatment options for metastatic melanoma, including both cytotoxic and immunologic therapies,
Tryfonopoulos, Dimitrios, Eustace, Alexander J., Mahgoub, Thamir, O\u27Donovan, Norma, Crown, John, O'Donovan, Norma   +5 more
core  

Treatment of cutaneous melanoma: current approaches and future prospects [PDF]

, 2010
Alain P Algazi1, Christopher W Soon2, Adil I Daud11Department of Medicine, Division of Hematology and Oncology, 2Department of Dermatology, University of California, San Francisco San Francisco, CA, USAAbstract: Melanoma is the most aggressive and deadly
Christopher W Soon, Adil I Daud, null Soon, Daud, Adil I, Adil Daud, null Daud, Alain P Algazi, Soon, Christopher W, Algazi, Alain P   +8 more
core   +1 more source

Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study

American Journal of Hematology, EarlyView.
ABSTRACT Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...
Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li   +11 more
wiley   +1 more source

Expressions of HLA Class II Genes in Cutaneous Melanoma Were Associated with Clinical Outcome: Bioinformatics Approaches and Systematic Analysis of Public Microarray and RNA-Seq Datasets

Diagnostics, 2019
Major histocompatibility complex (MHC) class II molecules, encoded by human leukocyte antigen (HLA) class II genes, play important roles in antigen presentation and initiation of immune responses.
Yang-Yi Chen, Wei-An Chang, En-Shyh Lin, Yi-Jen Chen, Po-Lin Kuo   +4 more
doaj   +1 more source

RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma

Biomolecules, 2021
Metastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogenesis
Paula Colón-Bolea, Rocío García-Gómez, Berta Casar   +2 more
doaj   +1 more source