Results 41 to 50 of about 64,436 (298)

An Analytical Approach to Cutter Edge Temperature Prediction in Milling and Its Application to Trochoidal Milling

Applied Sciences, 2020
Cutter edge temperature in milling is an important factor to cutter life. With high cutting speed and feedrate, the cutting efficiency is high; however, the cutter edge temperature is high, shortening the cutter life.
Qi Deng, Rong Mo, Zezhong C. Chen, Zhiyong Chang   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Land Grant Application- Cutter, William (West Cambridge) [PDF]

, 2017
Land grant application submitted to the Maine Land Office for William Cutter for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_mass/1107/thumbnail ...
Cutter, William
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Land Grant Application- Cutter, William (Medford) [PDF]

, 2017
Land grant application submitted to the Maine Land Office for William Cutter for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_mass/1106/thumbnail ...
Cutter, William
core  

Introducing a client-vendor model for DevOps implementation

, 2021
Successful transformation requires organizations to structure and operate in new ways, which requires creating many new patterns for designing teams and their collaborations with other groups. Anna Wiedemann et al.
Bartlett, Nick, Heiss, Dirk, Wiedemann, Anna, Krcmar, Helmut   +3 more
core   +2 more sources

Overseas Researches on PDC Cutters

Shiyou jixie, 2017
PDC cutters constitute the basic cutting unit of PDC bits,and its performance is crucial to the drilling effect of PDC bits.Overseas bit manufacturers have developed a series of new PDC cutters in order to improve the drilling efficiency in hard ...
Xu Lihui, Bi Siyi
doaj  

Study on the Cutter–Granite Interaction Mechanism in High-Temperature Geothermal Wells

Energies
In high-temperature geothermal wells, the formation usually has extremely high abrasiveness, hardness, and temperature, which pose severe challenges to drilling tools.
Yan Yang, Dongdong Song, Kuilin Huang, Haitao Ren, Yingxin Yang, Shunzuo Qiu, Zequan Huang   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source