Results 51 to 60 of about 64,436 (298)

ANALYSIS OF PROCESSING OF ARCHED FORMING ELEMENTS OF ROLLERS OF ROLLING PRESSES

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2016
A version of forming elements for rollers of rolling presses in the form of circumferential slots with a concave profile, forming arched lugs is proposed.
V. Ya. PRUSHAK, V. А. DANILOV, N. Yu. KONDRATCHIK   +2 more
doaj  

Influence of Cutter Width on Surface Roughness and Cutter Run Out During Horizontal Milling Operation [PDF]

Engineering and Technology Journal, 2010
This work focuses on studying the effect of cutter width on the surface roughness and cutter run out during horizontal milling operation, since the contact width in milling operations depends on the cutter geometry, especially (cutter diameter and width).
Saad Kareem Sather, Mohammad Naeem Houshi   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Design and Fabrication of An Automated Glass Bottle Cutter for Reuse and Recycling Bottle Glass Products

Journal of Engineering Technology and Applied Physics
The glass bottle cutter has a substantial commercialisation potential, as present trends indicate a growing interest in repurposing waste materials.
Alya Amanina binti Mohd Ishak, Ainaa Maya Munira Ismail, Ahmad Idzwan Yusuf, Ab Aziz Bin Mohd Yusof   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Model of Inverse Envelope Cutter with Ring-Involute Tooth [PDF]

, 2014
[[abstract]]The design of a conical cutter is important in the manufacture of concave and convex gears. An inverse method is presented for determining the mathematical model of a rack cutter.
Yang, Shyue-Cheng; Liu, Chi-Chia; Huang, Tsun-Hui
core  

Review of "Sacrifice and Self-Interest in Seventeenth-Century France: Quietism, Jansenism, and Cartesianism" by Elissa Cutter.

, 2020
Thomas M. Lennon. Sacrifice and Self-Interest in Seventeenth-Century France: Quietism, Jansenism, and Cartesianism. Brill’s Studies in Intellectual History 304. Leiden: Brill, 2019. xvii + 300 pp. $139.00.
Cutter, Elissa
core   +1 more source