Results 61 to 70 of about 64,436 (298)
Shiyou jixie, 2017 In view of the challenges of volcanic rocks in Junggar Basin like complex lithology, poor drillability and thick layer, the mechanics evaluation experiment of the volcanic rock in northwestern margin of the Junggar Basin has been carried out.
Yang Hu +5 more
doaj
Applied SciencesThe rock is the direct object of disc cutter rock-breaking engineering. It contains natural joint surface. To investigate the influence of joint-surface roughness on the rock-breaking process. The hob model is created using AutoCAD software.
Guoye Jing +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
An Interview with Martha J. Cutter, editor of MELUS
, 2014 NANO assistant editor Rebecca Devers interviews Martha J. Cutter, the former editor of MELUS, about the complexities of processing, reviewing, and publishing a journal that receives in over 300 submissions each year. An Interview with Martha J.
Martha J. Cutter, Rebecca Devers
core
Letter from Ruth Cutter Nash to Emmett L. Bennett Jr., September 04, 2004
, 2004 Ruth Cutter Nash writes Bennett of the 2004 summer at University of Cincinnati and of her current research on wine in the Linear B tablets and connections between commodities described in Cretan Hieroglyphic, Linear A and Linear B writings ...
Nash, Ruth Cutter
core +1 more source
AgricultureThis paper established an accurate discrete element for ultrasonic vibration-cutter-soil interaction model to study the interaction mechanism between the soil-engaging component and the soil.
Yang Qiao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source