Results 61 to 70 of about 241,686 (283)
Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]
, 2014 The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain +3 more
core +3 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Study on the Cutter–Granite Interaction Mechanism in High-Temperature Geothermal Wells
EnergiesIn high-temperature geothermal wells, the formation usually has extremely high abrasiveness, hardness, and temperature, which pose severe challenges to drilling tools.
Yan Yang +6 more
doaj +1 more source
, 1972 Replacement of opposing smooth rollers with appropriately grooved rollers in manual tubing cutter allows smooth severance of tubing of different diameters and eliminates raised lip around cut ...
Giandomenico, A.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Shiyou jixie, 2018 For the offshore well with a water depth of less than 800 m, the subsea wellhead system must be cut and recovered approximately 4 m under the mud line when the well is permanently abandoned, which is a key part of the permanent well abandonment operation.
Sun Zigang +4 more
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Phenolic cutter for machining foam insulation [PDF]
, 1970 Pre-pregged fiber glass is an efficient abrasive for machining polystyrene and polyurethane foams. It bonds easily to any cutter base made of aluminum, steel, or phenolic, is inexpensive, and is readily ...
Blair, T. A. +3 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Analysis of cutting parameters in point machining of parts with complex shape [PDF]
, 2018 This paper presents developed SW module in the postprocessor, which is designed to backward analysis of CAM milling toolpath. The module is designed to analyze multi-axis finishing machining of complex shape parts with milling cutters with a circular ...
Rybín J. +3 more
core