Results 91 to 100 of about 927,555 (356)

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Slicing Cuts on Food Materials Using Robotic-Controlled Razor Blade

open access: yesModelling and Simulation in Engineering, 2011
Cutting operations using blades can arise in a number of industries, for example, food processing industry, in which cheese, fruit and vegetable, even meat, are involved.
Debao Zhou, Gary McMurray
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

Machining state monitoring in end milling based on comparison of monitored and predicted cutting torques

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
To improve machining efficiency, it is necessary to know the machining status and optimize cutting conditions. Cutting force prediction is one method of determining the machining status.
Kazuki KANEKO   +3 more
doaj   +1 more source

A study on cutting forces in gear cutting. (Specific cutting forces by cutting tools with circular and straight edges)

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1987
As the cutting condition of generating gears such as in hobbing is very complex, the specific cutting forces are different from those of orthogonal turning. In general, the specific cutting forces in hobbing are large, since the flowing chips interfere on the tool face.
Toshio SUZUKI   +3 more
openaire   +2 more sources

Определение силы резания при глубоком безвыводном сверлении литейных алюминиев стандартными режущими инструментами [PDF]

open access: yes, 2004
It is investigated the influence of cutting conditions on cutting force at leadless peck feed drilling of cashable aluminum alloys on multithread machines.
Маршуба, Вячеслав Павлович
core  

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Simulation analysis of shearer drum cutting coal-rock under oblique cutting conditio

open access: yesGong-kuang zidonghua, 2018
In order to study movement rule and force characteristic of shearer drum under oblique cutting condition, virtual prototype model of shearer under oblique cutting condition was established by use of ADAMS, and movement curve of shearer drum was obtained ...
YUAN Bin, WANG Yiliang, YANG Zhaojian
doaj   +1 more source

Development of an in-house cutting forces simulation for fir tree broaching process [PDF]

open access: yes, 2014
This article proposes a simulation of cutting forces in broaching of fir tree slots. Every step needed to build an in-house fir tree broaching simulation is presented.
Cazenave-Larroche, Gilles   +5 more
core   +4 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

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