Results 51 to 60 of about 21,838 (295)

A mechanistic approach to predict cutting forces based on cutting force coefficients in slot milling Al-7075

, 2022
Abstract The force in metal cutting is a crucial factor that determines surface quality, tool wear, and cutting stability. It has a significant role in defining the power requirement, machine and cutting tool specifications which govern the overall machining time and cost.
Rahul A Mali, Satish Chinchanikar, T. V. K. Gupta   +2 more
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cutting torque and tangential cutting force coefficient identification from spindle motor current [PDF]

, 2018
This article presents an enhanced methodology for cutting torque prediction from the spindle motor current, readily available in modern machine tool controllers.
Nešić, Nenad, Aggarwal, Saurabh, Xirouchakis, Paul   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A development method of cutting force coefficients in face milling process using parallelogram insert

, 2021
This paper presents a modeling method of cutting force and a combination approach of theory and experimental methods in the determination of cutting force coefficients in the face milling process using a parallelogram insert.
Nguyen, N. (Nhu-Tung), Nguyen, Nhu-Tung
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Chatter Stability in Turning and Milling with in Process Identified Process Damping

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Process damping in metal cutting is caused by the contact between the flank face of the cutting tool and the wavy surface finish, which is known to damp chatter vibrations.
Yusuke KURATA, S. Doruk MERDOL, Yusuf ALTINTAS, Norikazu SUZUKI, Eiji SHAMOTO   +4 more
doaj   +1 more source

Modeling and Predicting Cutting Force in Precision Hard Turning

, 2011
This paper proposes a new approach to modeling the cutting force, based on friction behavior on tool-chip interface in precision hard turning. The modeling touches on such researches as into experimental relationship between cutting force and cutting ...
Tao Chen, F.G. Yan, H.Y. Han, Yun Peng Ding, J.S. Hu   +4 more
core   +1 more source