Results 111 to 120 of about 2,344,781 (356)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

INFLUENCE OF CUTTING INSERTS IN MACHINING Al-Si ALLOY-BASED METAL MATRIX COMPOSITES [PDF]

open access: yesProceedings on Engineering Sciences
To better comprehend the machinability studies during MMCs, the effect of cutting tool while machining MMCs, the cutting forces that induce and importantly the influence of cutting tool were carried out.
Sudheer Reddy J , Vikram Kedambadi Vasu
doaj   +1 more source

A predictive model for the cutting force in wood machining developed using mechanical properties [PDF]

open access: yes, 2012
In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Clahr, Emil   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

????????????????????? ?????? ????????? ??????????????? ???????????? ?????? ????????? [PDF]

open access: yes, 2017
The surface roughness and cutting forces are the important factors for the machine-part quality during the hard-turning process. The aim of this paper is to optimize hard-cutting conditions via implementation of response surface methodology (RSM).
Kim, Do Young   +2 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Grinding Process Results with Oil Mist. [PDF]

open access: yes, 2016
The paper presents a study of the process of grinding titanium grinding wheels with mikrokorundu, sanding at surfaces involving liquid - cooling lubricants using MQL, used machining fluid - propylene glycol and other liquids business dedicated to the ...
Wejman, Przemysław, Wójcik, Ryszard
core  

Module the measurement of forces cutting [PDF]

open access: yes, 2016
Мета. Створення універсального комплексу по вимірюванню сил різання динамічних процесів в реальному часі. Методика. На базі аналізу датчиків для вимірювання сил різання, прийнято, для динамічних процесів, тензодатчик.
Maidaniyk, S.   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Health Hazard Manual For Cutting Oils, Coolants, and Metalworking Fluids [PDF]

open access: yes, 1991
[Excerpt] The metalworker can be exposed to cutting oils during application by two basic routes of entry: skin contact and inhalation. The higher risk jobs tend to be those with high cutting speeds, heavy oil flow, and continuous contact, which may ...
Brown, Nellie J
core   +1 more source

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