Results 81 to 90 of about 2,344,781 (356)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Modelling High Speed Machining with the SPH Method [PDF]
, 2008 The purpose of this work is to evaluate the use of the Smoothed Particle Hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
Chieragatti, Rémy +5 more
core
Machining cobalt-based dental alloys with tungsten carbide mills [PDF]
, 2014 Milling characteristics of dental alloys have been investigated and compared. The four differently configured tools used were made of cemented tungsten carbide. Most were uncoated but one was coated with a diamond-like carbon layer.
Hirotaka ONO +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
THE INFLUENCE OF THE FUNCTIONAL GEOMETRY OF THE CUTTING TOOLON THE MAINCUTTINGFORCE IN THE STRING OPERATION [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018 he quality of the machined parts is strongly influenced by the rigidity of the technological system, but also by the size and variation of the forces that occur during the cutting process.
D. Dobrotă, M. Tomescu
doaj
Process simulation for 5-axis machining using generalized milling tool geometries [PDF]
, 2010 Multi-axis machining (especially 5-axis machining) is widely used in precision machining for automotive, aerospace and die-mold manufacturing. The goal in precision machining is to increase production while meeting high part quality needs which can be ...
Budak, Erhan +2 more
core
DEM simulation of soil-tool interaction under extraterrestrial environmental effects [PDF]
, 2017 In contrast to terrestrial environment, the harsh lunar environment conditions include lower gravity acceleration, ultra-high vacuum and high (low) temperature in the daytime (night-time).
Arroyo Alvarez de Toledo, Marcos +3 more
core +2 more sources
Force-frequency effect of Y-cut langanite and Y-cut langatate [PDF]
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2003 Most recently, langasite and its isomorphs (LGX) have been advanced as potential substitutes for quartz, owing to their extremely high-quality (Q) factors. At least twice higher Q value of LGX than that of quartz has been reported. High Q translates into potentially greater stability.
Yoonkee, Kim, Arthur, Ballato
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Simultaneous Clamping and Cutting Force Measurements with Built-In Sensors
Sensors, 2020 The intensity of the clamping force during milling operations is very important, because an excessive clamping force can distort the workpiece, while inadequate clamping causes slippage of the workpiece.
Sina Rezvani +3 more
doaj +1 more source