Results 71 to 80 of about 390,130 (351)

The study of end milling temperature of low-alloy steel in coarse-grained and ultrafine-grained states

Frontier Materials & Technologies
The paper presents the results of the study of the end milling temperature of low-alloy steel depending on the cutting modes and the type of crystalline structure. The experiment was carried out on a PROMA FHV-50PD universal milling machine.
Dmitry A. Rastorguev, Aleksandr A. Sevastyanov, Gennady V. Klevtsov   +2 more
doaj   +1 more source

Design development of machine shop area for the case TSF-8.171.137 manufacture including the study of cutting tool geometrical parameters influence on cutting force parameters [PDF]

, 2019
The thesis develops the design of machine shop area for manufacturing the case and researching the impact of cutting tool geometrical parameters on cutting force components and tool lifeCONTENTS INTRODUCTION 1. ANALYTIC CHAPTER 1.1.
Duhair, Yousif, Духаір, Юсіф
core  

Simulation of a finishing operation : milling of a turbine blade and influence of damping [PDF]

, 2012
Milling is used to create very complex geometries and thin parts, such as turbine blades. Irreversible geometric defects may appear during finishing operations when a high surface quality is expected.
BALMES, Etienne, COFFIGNAL, Gérard, GUSKOV, Mikhail, LORONG, Philippe, TEXIER, Anthony   +4 more
core   +5 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Modelling and mechanical characteristics of PDC cutter-rock interaction by combining mixed fragmentation modes with dynamic rock strength

Petroleum
Polycrystalline diamond compact (PDC) bit is one of the most widely used drill bits for improving the rate of penetration in deep oil and gas well and geothermal well.
Guangjian Dong, Ping Chen, Xudong Wang, Jianhong Fu, Yingxin Yang   +4 more
doaj   +1 more source

DETAILS’ REPAIR OF CONSTRUCTION AND ROAD MACHINES: FLUCTUATIONS’ MODELLING

Вестник СибАДИ, 2019
Introduction. Hole details are quite widely used in structures of construction and road machines. The specialists apply boring for draft, semi-fair, and in some cases for fair processing of such surfaces.
V. E. Ovsyannikov, V. I. Vasilyev
doaj   +1 more source

Оптимизация режимов резания при обработке на тяжелых токарных станках с учетом энергозатрат [PDF]

, 2010
Приведены результаты исследования влияния режимов резания токарной обработки на энергозатраты и их выбор с точки зрения минимизации этих расходов.Results of research of influencing the modes of cutting on the expenditures of energy.
Васильева, Л. В., Гузенко, В. С., Мироненко, Е. В., Мироненко, О. Е.   +3 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A model of lathe dynamic system when cutting hard-to-work materials

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. Ensuring the surface quality of critical products of aviation equipment, chemical, power engineering, transport systems for various purposes presents certain requirements for the equipment on which surface formation is carried out.
A.A. Ignat'ev, T.G. Nasad, V.A. Dobryakov, V.A. Revyakin   +3 more
doaj   +1 more source