Results 91 to 100 of about 1,078,585 (298)
The Performance of TiAlSiN Coated Cemented Carbide Tools Enhanced by Inserting Ti Interlayers
Metals, 2019 To enhance the cutting performance of TiAlSiN coated cemented carbide tools by inserting Ti interlayers and to explore their mechanism, TiAlSiN/Ti multilayer coatings with different Ti thicknesses, including 0 nm, 25 nm, 50 nm, 100 nm, and 150 nm, were ...
Guodong Li +7 more
doaj +1 more source
Energy Efficiency Improvements in Dry Drilling with Optimised Diamond-Like Carbon Coating [PDF]
, 2008 We demonstrate enhancements of performance and energy efficiency of cutting tools by deposition of diamond-like carbon (DLC) coatings on machine parts. DLC was deposited on steel drill bits, using plasma enhanced chemical vapour deposition (PECVD) with ...
A.W. Anson +16 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Cutting Performance and Wear/Damage Characteristics of PCBN Tool in Hard Milling
Applied Sciences, 2019 In the intermittent machining of hardened steel for the die and mold industry, determining how to reduce the wear of PCBN (Polycrystalline Cubic Boron Nitride) tools and improve their machining efficiency and quality is an important subject.
Haining Gao, Xianli Liu, Zhitao Chen
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
LubricantsCutting fluid has been widely used to enhance the heat dissipation of cutting systems. However, whether cutting fluid can fully play its role is closely correlated with its thermophysical characteristics, such as viscosity, surface tension, etc.
Xiaorong Zhou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
MetalsThis study addresses the limited research on the mechanical behavior and cutting performance of additive manufactured cemented carbides with high TiC content, which has impeded the rapid development of additive manufacturing in carbide cutting tools ...
Bisheng Zhong +3 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source