Results 111 to 120 of about 1,078,585 (298)
MachinesCarbide tools are extensively used in the automotive, aerospace, and marine industries. However, an unsuitable tool-edge treatment can affect the cutting performance of carbide tools.
Shitao Chen +9 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Influence of Multiple Used Implant Drills on Their Cutting Performance and Fracture Resistance. [PDF]
Materials (Basel), 2023 Alevizakos V, Mosch R, von See C.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
MetalsThe relationship between the stability of tool materials and their cutting performance is a critical technical challenge for the manufacturing industry, which is essential for selecting appropriate treatment processes to achieve superior treatment tool ...
Fujian Guo +6 more
doaj +1 more source
Design and Test Research on Cutting Blade of Corn Harvester Based on Bionic Principle
Applied Bionics and Biomechanics, 2017 Existing corn harvester cutting blades have problems associated with large cutting resistance, high energy consumption, and poor cut quality. Using bionics principles, a bionic blade was designed by extracting the cutting tooth profile curve of the B ...
Kunpeng Tian +5 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Preparation and cutting performance study of YSZ-toughened PcBN superhard tools. [PDF]
RSC Adv, 2023 Yue Y, Zhu Y, Li Z.
europepmc +1 more source
Towards self-optimizing and self-adaptive milling processes [PDF]
This paper presents a novel control architecture system which is composed of a multi-objective cost function which Pareto optimises the programming of cutting parameters while adapting the milling process to new cutting conditions if new constraints ...
Fletcher, Simon +3 more
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