Results 121 to 130 of about 1,078,585 (298)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Apparatus for monitoring linear explosive performance [PDF]

, 1974
Techniques provide performance monitoring standard for acceptance, lot qualification, and comparison testing of devices. Exhibit high degree of simplicity, accuracy, and reproducibility.
Bement, L. J.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Comprehensive Understanding of Knife Cutting: Effects of Hardness, Blade Angle and the Micro-Geometry of Blade Edge on the Cutting Performance. [PDF]

Materials (Basel), 2023
Zhang Q, Liu F, Wu D, Qu S, Liu W, Chen Z.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effect of Garnet Characteristics on Abrasive Waterjet Cutting of Hard Granite Rock

Advances in Civil Engineering, 2019
Abrasive waterjet cutting technology has come back into use in the field of rock excavation (such as for tunneling) due to the need for precision construction with low vibration.
Tae-Min Oh, Gun-Wook Joo, Yohan Cha, Gye-Chun Cho   +3 more
doaj   +1 more source

Effect of Coating Thickness on Abrasion and Cutting Performance of NCD-Coated Ball Endmills on Graphite Machining. [PDF]

Micromachines (Basel), 2023
Lee H, Kim J, Lee S, Park J, Park J, Kim J.   +5 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analysis and optimization of micro-pit texture parameters on surface of turning tool for GH4169 nickel-based superalloy

Jin'gangshi yu moliao moju gongcheng
ObjectivesGH4169 nickel-based high-temperature alloy is widely used in aerospace and energy equipment fields due to its excellent high-temperature resistance and corrosion resistance, but its difficult-to-machine characteristics lead to high cutting ...
Shankuo YUE, Yan HE, Shuyuan SONG, Lin FAN, Meiling TANG, Jingting SUN   +5 more
doaj   +1 more source

Development of a Cutting Technique Modification Training Program and Evaluation of its Effects on Movement Quality and Cutting Performance in Male Adolescent American Football Players. [PDF]

Sports (Basel), 2023
Thieschäfer L, Klütz J, Weig J, Dos'Santos T, Büsch D.   +4 more
europepmc   +1 more source